| Gene Symbol |
NAMPT
|
| Entrez Gene |
10135
|
| Alt Symbol |
1110035O14Rik, PBEF, PBEF1, VF, VISFATIN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nicotinamide phosphoribosyltransferase
|
| Other Description |
NAmPRTase|pre-B cell-enhancing factor|pre-B-cell colony enhancing factor 1|pre-B-cell colony-enhancing factor 1
|
| Swissprots |
P43490 A4D0Q9 Q3KQV0 A4D0R0 Q8WW95
|
| Accessions |
AAF19249 AAQ96862 CAM12699 CAN36300 CAV30744 CBX74360 CBX78820 EAL24399 EAL24400 EAW83382 EAW83383 EAW83384 P43490 AI299587 AK023341 AK292851 BAF85540 AK304085 BAH14102 AL832518 CAH56351 BC020691 BC072439 AAH72439 BC106046 AAI06047 BI859562 HQ447548 ADQ32034 L29050 U02020 AAA17884 XM_005250100 XP_005250157 XM_011515707 XP_011514009 NM_005746 NP_005737 NM_182790
|
| Function |
Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:24130902}. Cytoplasm {ECO:0000250|UniProtKB:Q99KQ4}. Secreted {ECO:0000269|PubMed:21741723}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000269|PubMed:21741723, ECO:0000269|PubMed:24130902}.
|
| Tissue Specificity |
Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.
|
| Top Pathways |
Nicotinate and nicotinamide metabolism
|