NAMPT

Gene Symbol	NAMPT
Entrez Gene	10135
Alt Symbol	1110035O14Rik, PBEF, PBEF1, VF, VISFATIN
Species	Human
Gene Type	protein-coding
Description	nicotinamide phosphoribosyltransferase
Other Description	NAmPRTase|pre-B cell-enhancing factor|pre-B-cell colony enhancing factor 1|pre-B-cell colony-enhancing factor 1
Swissprots	P43490 A4D0Q9 Q3KQV0 A4D0R0 Q8WW95
Accessions	AAF19249 AAQ96862 CAM12699 CAN36300 CAV30744 CBX74360 CBX78820 EAL24399 EAL24400 EAW83382 EAW83383 EAW83384 P43490 AI299587 AK023341 AK292851 BAF85540 AK304085 BAH14102 AL832518 CAH56351 BC020691 BC072439 AAH72439 BC106046 AAI06047 BI859562 HQ447548 ADQ32034 L29050 U02020 AAA17884 XM_005250100 XP_005250157 XM_011515707 XP_011514009 NM_005746 NP_005737 NM_182790
Function	Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:24130902}. Cytoplasm {ECO:0000250|UniProtKB:Q99KQ4}. Secreted {ECO:0000269|PubMed:21741723}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000269|PubMed:21741723, ECO:0000269|PubMed:24130902}.
Tissue Specificity	Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.
Top Pathways	Nicotinate and nicotinamide metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Visfatin full length protein - ab198458 from Abcam Category Protein Prices $1,004.00 Sizes 50 µg Source E. coli Species Human

Active human Visfatin full length protein - ab198090 from Abcam Category Protein Prices $359.00 Sizes 50 µg Source E. coli Species Human

Active human Visfatin protein fragment - ab179498 from Abcam Category Protein Prices $184.00 Sizes 25 µg Source E. coli Species Human

Active mouse Visfatin full length protein - ab62617 from Abcam Category Protein Prices $257.00 Sizes 10 µg Source E. coli Species Mouse

Human Visfatin full length protein - ab52323 from Abcam Category Protein Source E. coli Species Human

Human Visfatin full length protein - ab109137 from Abcam Category Protein Source HEK 293 cells Species Human

Human Visfatin full length protein - ab62615 from Abcam Category Protein Source E. coli Species Human

Human Visfatin protein fragment - ab63275 from Abcam Category Protein Source E. coli Species Human

Human Visfatin protein fragment - ab50134 from Abcam Category Protein Source E. coli Species Human

Rat Visfatin full length protein - ab109143 from Abcam Category Protein Source HEK 293 cells Species Rat

Rat Visfatin protein fragment - ab62614 from Abcam Category Protein Source E. coli Species Rat

Visfatin peptide - ab45889 from Abcam Category Peptide

NAMPT / Visfatin Antibody Blocking Peptide - LS-E9900 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PBEF/Visfatin/NAMPT Recombinant Protein - H00010135-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PBEF/Visfatin/NAMPT Protein - NBC1-18484 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

PBEF/Visfatin/NAMPT Recombinant Protein - P4162 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PBEF/Visfatin/NAMPT Protein - NBP1-99182 from Novus Biologicals Category Protein Species Human

PBEF/Visfatin/NAMPT Protein - NBP1-99618 from Novus Biologicals Category Protein Prices $469.00 Sizes 50 µg Species Human

NAMPT-Antibody-Center-Blocking-Peptide - BP9010c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Visfatin recombinant protein - GTX65312 from GeneTex Category Protein Prices $199.00 Sizes 10 μg Source E. coli Species Human

Visfatin recombinant protein - GTX65311 from GeneTex Category Protein Prices $359.00 Sizes 50 μg Source E. coli Species Human

Visfatin Recombinant Protein (Active) - GTX48323-PRO from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

Recombinant Human PBEF/Visfatin, CF - 8424-VF-050 from R&D Systems Category Protein Source E. coli-derived, Asn2-His491, with an N-terminal Met and 6-His tag

PBEF1 Protein Lysate (APL10259) - APL10259 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

PBEF1 Protein Lysate (APL10263) - APL10263 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

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