PAPPA

Gene Symbol	PAPPA
Entrez Gene	5069
Alt Symbol	ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1
Species	Human
Gene Type	protein-coding
Description	pregnancy-associated plasma protein A, pappalysin 1
Other Description	IGF-dependent IGFBP-4 protease\|aspecific BCL2 ARE-binding protein 2\|differentially placenta 1 expressed protein\|insulin-like growth factor-dependent IGF binding protein-4 protease\|insulin-like growth factor-dependent IGF-binding protein 4 protease\|pappalysin-1\|pregnacy-associated plasma protein A
Swissprots	B1AMF9 Q9UDK7 Q08371 Q13219 Q68G52
Accessions	AAV41521 CBH19408 EAW87439 EAW87440 EAW87441 EAW87442 Q13219 AF085834 AF085855 AJ420429 AJ420467 AK024330 AK092441 AK094182 AK129714 AK300128 BAG61919 AK300129 BAG61920 AK308154 AU139179 AY140907 AAN25598 AY189937 AAO25648 AY302185 AAP68818 AY623010 AAV41518 BC029404 BC054010 BC057782 BC062657 BC078657 AAH78657 BG572566 BG622932 BG623020 BU158714 CB960120 CB988079 CB989873 R75872 W04151 X68280 CAA48341 XM_006717129 XP_006717192 NM_002581 NP_002572
Function	Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. {ECO:0000269\|PubMed:10077652, ECO:0000269\|PubMed:10913121, ECO:0000269\|PubMed:11522292}.
Subcellular Location	Secreted {ECO:0000269\|PubMed:10077652}.
Tissue Specificity	High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts. {ECO:0000269\|PubMed:10077652, ECO:0000269\|PubMed:10491647, ECO:0000269\|PubMed:7508748, ECO:0000269\|PubMed:7526035}.

PAPP-A (H-175) - sc-50518 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

PAPP-A (H-175): sc-50518. Western blot analysis of PAPP-A expression in non-transfected: sc-110760 (A) and mouse PAPP-A transfected: sc-179290 (B) 293 whole cell lysates.

PAPP-A (B-7) - sc-365226 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

PAPP-A (B-7): sc-365226. Western blot analysis of PAPP-A expression in non-transfected: sc-110760 (A) and mouse PAPP-A transfected: sc-179290 (B) 293 whole cell lysates.

PAPP-A (C-14) - sc-47300 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

PAPP-A (D-15) - sc-47301 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-PAPP A antibody - ab203683 from Abcam

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of formalin-fixed, paraffin-embedded mouse embryo tissue labeling PAPP A with ab203683 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Anti-PAPP A antibody - ab200374 from Abcam

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue labeling PAPP A with ab200374 at 1/50 dilution.

Anti-PAPP A antibody - ab59087 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-PAPP A antibody (ab59087) at 1/1000 dilutionLane 1 : Recombinant Human Pappalysin-1 at 0.04 µgLane 2 : Recombinant Human Pappalysin-1 at 0.02 µgLane 3 : Recombinant Human Pappalysin-1 at 0.01 µgLane 4 : Recombinant Human Pappalysin-1 at 0.005 µgLane 5 : Recombinant Human Pappalysin-2 at 0.04 µgLane 6 : Recombinant Human Pappalysin-2 at 0.02 µgLane 7 : Recombinant Human Pappalysin-2 at 0.01 µgLane 8 : Recombinant Human Pappalysin-2 at 0.005 µg

Anti-PAPP A antibody - ab59088 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-PAPP A antibody (ab59088) at 1/1000 dilutionLane 1 : Recombinant Human Pappalysin-1 at 0.04 µgLane 2 : Recombinant Human Pappalysin-1 at 0.02 µgLane 3 : Recombinant Human Pappalysin-1 at 0.01 µgLane 4 : Recombinant Human Pappalysin-1 at 0.005 µgLane 5 : Recombinant Human Pappalysin-2 at 0.04 µgLane 6 : Recombinant Human Pappalysin-2 at 0.02 µgLane 7 : Recombinant Human Pappalysin-2 at 0.01 µgLane 8 : Recombinant Human Pappalysin-2 at 0.005 µg

Anti-PAPP A antibody - ab59090 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-PAPP A antibody (ab59090) at 1/1000 dilutionLane 1 : Recombinant Human Pappalysin-1 at 0.04 µgLane 2 : Recombinant Human Pappalysin-1 at 0.02 µgLane 3 : Recombinant Human Pappalysin-1 at 0.01 µgLane 4 : Recombinant Human Pappalysin-1 at 0.005 µgLane 5 : Recombinant Human Pappalysin-2 at 0.04 µgLane 6 : Recombinant Human Pappalysin-2 at 0.02 µgLane 7 : Recombinant Human Pappalysin-2 at 0.01 µgLane 8 : Recombinant Human Pappalysin-2 at 0.005 µg

Anti-PAPP A antibody - ab59093 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PAPP A antibody [004-09] - ab52030 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	004-09

Ab52030 staining human PAPP A in human placenta tissue by immunohistochemistry using frozen tissue. Staining (red-brown) is restricted to the syncytiotrophoblast of the chorionic villi.

Anti-PAPP A antibody [10A5] - ab10193 from Abcam

Prices	$370.00
Sizes	250 µg
Host	Mouse
Clonality	Monoclonal
Clone	10A5

Anti-PAPP A antibody [10E1] (HRP) - ab8346 from Abcam

Prices	$370.00
Sizes	200 µg
Host	Mouse
Clonality	Monoclonal
Clone	10E1

Anti-PAPP A antibody [10E2] - ab8347 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	10E2

Anti-PAPP A antibody [10H9] (HRP) - ab10195 from Abcam

Prices	$370.00
Sizes	200 µg
Host	Mouse
Clonality	Monoclonal
Clone	10H9

PAPP A calibration curve for two assays Capture: biotinylated ab10192; 200 ng/well Detection: Eu-labeled ab10194; 400 ng/well (light blue); Eu-labeled 10195, 200 ng/well (dark blue). Strep avidin coated plates. Assay time: 30 min, room temperature.

Anti-PAPP A antibody [11E4] - ab14597 from Abcam

Prices	$370.00
Sizes	250 µg
Host	Mouse
Clonality	Monoclonal
Clone	11E4

Anti-PAPP A antibody [18A10] - ab10196 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	18A10

Anti-PAPP A antibody [3C8] (HRP) - ab24463 from Abcam

Prices	$370.00
Sizes	200 µg
Host	Mouse
Clonality	Monoclonal
Clone	3C8

Anti-PAPP A antibody [4G11] - ab10192 from Abcam

Prices	$370.00
Sizes	500 µg
Host	Mouse
Clonality	Monoclonal
Clone	4G11

Anti-PAPP A antibody [5H9] (HRP) - ab10191 from Abcam

Prices	$370.00
Sizes	200 µg
Host	Mouse
Clonality	Monoclonal
Clone	5H9

Anti-PAPP A antibody [7A6] - ab90488 from Abcam

Prices	$370.00
Sizes	500 µl
Host	Mouse
Clonality	Monoclonal
Clone	7A6

Anti-PAPP A antibody [EPR12897] - ab174314 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR12897

Anti-PAPP A antibody [EPR12897] (ab174314) at 1/1000 dilution + Human placenta lysate at 10 µg

Anti-PAPPA / PAPP-A Antibody - LS-C194537 from LifeSpan Bioscience

Prices	$435.00
Sizes	1 mg
Host	Mouse
Clonality	Monoclonal

Anti-PAPPA / PAPP-A Antibody - LS-C194538 from LifeSpan Bioscience

Prices	$435.00
Sizes	1 mg
Host	Mouse
Clonality	Monoclonal

Anti-PAPPA / PAPP-A Antibody - LS-C285667 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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