PAPPA

Gene Symbol	PAPPA
Entrez Gene	5069
Alt Symbol	ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1
Species	Human
Gene Type	protein-coding
Description	pregnancy-associated plasma protein A, pappalysin 1
Other Description	IGF-dependent IGFBP-4 protease|aspecific BCL2 ARE-binding protein 2|differentially placenta 1 expressed protein|insulin-like growth factor-dependent IGF binding protein-4 protease|insulin-like growth factor-dependent IGF-binding protein 4 protease|pappalysin-1|pregnacy-associated plasma protein A
Swissprots	B1AMF9 Q9UDK7 Q08371 Q13219 Q68G52
Accessions	AAV41521 CBH19408 EAW87439 EAW87440 EAW87441 EAW87442 Q13219 AF085834 AF085855 AJ420429 AJ420467 AK024330 AK092441 AK094182 AK129714 AK300128 BAG61919 AK300129 BAG61920 AK308154 AU139179 AY140907 AAN25598 AY189937 AAO25648 AY302185 AAP68818 AY623010 AAV41518 BC029404 BC054010 BC057782 BC062657 BC078657 AAH78657 BG572566 BG622932 BG623020 BU158714 CB960120 CB988079 CB989873 R75872 W04151 X68280 CAA48341 XM_006717129 XP_006717192 NM_002581 NP_002572
Function	Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. {ECO:0000269|PubMed:10077652, ECO:0000269|PubMed:10913121, ECO:0000269|PubMed:11522292}.
Subcellular Location	Secreted {ECO:0000269|PubMed:10077652}.
Tissue Specificity	High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts. {ECO:0000269|PubMed:10077652, ECO:0000269|PubMed:10491647, ECO:0000269|PubMed:7508748, ECO:0000269|PubMed:7526035}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse PAPPA / PAPP-A ELISA Kit (Sandwich ELISA) - LS-F4037 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 146 pg/ml Range 0.686-166.7 ng/ml

Human PAPPA / PAPP-A ELISA Kit (Sandwich ELISA) - LS-F4036 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 31.25 pg/ml Range 0.686-166.7 ng/ml

Human PAPPA / PAPP-A ELISA Kit (Sandwich ELISA) - LS-F12256 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 62.5 Range 0.686-166.7 ng/ml

Human PAPPA / Pappalysin-1 ELISA Kit - RAB0720 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Human Pappalysin-1/PAPP-A Luminex Performance Assay - LUCA2487 from R&D Systems

Human Pappalysin-1/PAPP-A Quantikine ELISA Kit - DPPA00 from R&D Systems Category ELISA Kit Prices $509.00 Sizes 1 kit Sensitivity 0.116 ng/mL Range 0.8 - 50 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)

Human Pappalysin-1/PAPP-A DuoSet ELISA - DY2487-05 from R&D Systems Category ELISA Kit Prices $299.00 Sizes 1 kit (for 5 Plates) Range 0.78 - 50 ng/mL

Human PAPP-A ELISA Kit - abx054536 from Abbexa Category ELISA Kit Sensitivity 0.01 ng/ml Range 0.06 ng/ml -4 ng/ml

Human PAPPA ELISA Kit - abx152636 from Abbexa Category ELISA Kit Sensitivity 0.116 ng/ml Range 0.313 ng/ml - 20 ng/ml

PAPP-A, Human, ELISA - IB79116 from ARP American Research Products Category ELISA Kit Prices $459.00 Sizes 96 t

Pregnancy Associated Plasma Protein A, PAPPA, Human, ELISA Kit - E-EL-H0145 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.469 Range 0.781-50ng/mL

Pappalysin-1, PAPPA, Human, ELISA Kit - E0800h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 62.5-4000 pg/mL

Pregnancy Associated Plasma Protein A (PAPPA), Human, ELISA Kit - SEA800Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.116ng/mL Range 0.312-20ng/mL

Pregnancy associated plasma protein A, PAPP-A, Human, ELISA Kit - CSB-E08220h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

pregnancy associated plasma protein A, PAPP-A, Mouse, ELISA Kit - E-EL-M0940 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Pregnancy Associated Plasma Protein A, PAPPA, Mouse, ELISA Kit - E-EL-M0087 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Pregnancy Associated Plasma Protein A, PAPPA, Rat, ELISA Kit - E-EL-R0056 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Pregnancy Associated Plasma Protein A/Pappalysin-1, PAPPA, Rabbit, ELISA Kit - E-EL-RB1915 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Pregnancy Associated Plasma Protein A/Pappalysin-1, PAPPA, Chicken, ELISA Kit - E-EL-Ch1280 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Pregnancy Associated Plasma Protein A/Pappalysin-1, PAPPA, Porcine, ELISA Kit - E-EL-P1513 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Pregnancy Associated Plasma Protein A/Pappalysin-1, PAPPA, Monkey, ELISA Kit - E-EL-MK1397 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

PAPP-A ELISA Kit - KA1281 from Acris Antibodies Category ELISA Kit Prices $380.00 Sizes 1 kit

Human PAPP-A ELISA - ELH-PAPPA from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 0.6 ng/ml Range 0.6 ng/ml - 500 ng/ml

Human PAPP-A ELISA Kit - HP0618 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine PAPP-A ELISA Kit - AP0618 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

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