| Gene Symbol |
PAPPA
|
| Entrez Gene |
5069
|
| Alt Symbol |
ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pregnancy-associated plasma protein A, pappalysin 1
|
| Other Description |
IGF-dependent IGFBP-4 protease|aspecific BCL2 ARE-binding protein 2|differentially placenta 1 expressed protein|insulin-like growth factor-dependent IGF binding protein-4 protease|insulin-like growth factor-dependent IGF-binding protein 4 protease|pappalysin-1|pregnacy-associated plasma protein A
|
| Swissprots |
B1AMF9 Q9UDK7 Q08371 Q13219 Q68G52
|
| Accessions |
AAV41521 CBH19408 EAW87439 EAW87440 EAW87441 EAW87442 Q13219 AF085834 AF085855 AJ420429 AJ420467 AK024330 AK092441 AK094182 AK129714 AK300128 BAG61919 AK300129 BAG61920 AK308154 AU139179 AY140907 AAN25598 AY189937 AAO25648 AY302185 AAP68818 AY623010 AAV41518 BC029404 BC054010 BC057782 BC062657 BC078657 AAH78657 BG572566 BG622932 BG623020 BU158714 CB960120 CB988079 CB989873 R75872 W04151 X68280 CAA48341 XM_006717129 XP_006717192 NM_002581 NP_002572
|
| Function |
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. {ECO:0000269|PubMed:10077652, ECO:0000269|PubMed:10913121, ECO:0000269|PubMed:11522292}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:10077652}.
|
| Tissue Specificity |
High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts. {ECO:0000269|PubMed:10077652, ECO:0000269|PubMed:10491647, ECO:0000269|PubMed:7508748, ECO:0000269|PubMed:7526035}.
|