PAPPA

Gene Symbol PAPPA
Entrez Gene 5069
Alt Symbol ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1
Species Human
Gene Type protein-coding
Description pregnancy-associated plasma protein A, pappalysin 1
Other Description IGF-dependent IGFBP-4 protease|aspecific BCL2 ARE-binding protein 2|differentially placenta 1 expressed protein|insulin-like growth factor-dependent IGF binding protein-4 protease|insulin-like growth factor-dependent IGF-binding protein 4 protease|pappalysin-1|pregnacy-associated plasma protein A
Swissprots B1AMF9 Q9UDK7 Q08371 Q13219 Q68G52
Accessions AAV41521 CBH19408 EAW87439 EAW87440 EAW87441 EAW87442 Q13219 AF085834 AF085855 AJ420429 AJ420467 AK024330 AK092441 AK094182 AK129714 AK300128 BAG61919 AK300129 BAG61920 AK308154 AU139179 AY140907 AAN25598 AY189937 AAO25648 AY302185 AAP68818 AY623010 AAV41518 BC029404 BC054010 BC057782 BC062657 BC078657 AAH78657 BG572566 BG622932 BG623020 BU158714 CB960120 CB988079 CB989873 R75872 W04151 X68280 CAA48341 XM_006717129 XP_006717192 NM_002581 NP_002572
Function Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. {ECO:0000269|PubMed:10077652, ECO:0000269|PubMed:10913121, ECO:0000269|PubMed:11522292}.
Subcellular Location Secreted {ECO:0000269|PubMed:10077652}.
Tissue Specificity High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts. {ECO:0000269|PubMed:10077652, ECO:0000269|PubMed:10491647, ECO:0000269|PubMed:7508748, ECO:0000269|PubMed:7526035}.

PAPP-A CRISPR/Cas9 KO Plasmid (h) - sc-406222 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PAPP-A HDR Plasmid (h) - sc-406222-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PAPP-A Double Nickase Plasmid (h) - sc-406222-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PAPP-A Double Nickase Plasmid (h2) - sc-406222-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PAPP-A CRISPR Activation Plasmid (h) - sc-406222-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PAPP-A CRISPR Activation Plasmid (h2) - sc-406222-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PAPP-A Lentiviral Activation Particles (h) - sc-406222-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PAPP-A Lentiviral Activation Particles (h2) - sc-406222-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PAPP-A siRNA (h) - sc-61289 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PAPP-A shRNA Plasmid (h) - sc-61289-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PAPP-A shRNA (h) Lentiviral Particles - sc-61289-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Pappalysin-1/PAPP-A RNAi - H00005069-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU128981 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU067371 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16319 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16319 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PAPPA siRNA (Human) - CRH3369 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PAPP-A CRISPR/Cas9 KO Plasmid (h2) - sc-406222-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PAPP-A HDR Plasmid (h2) - sc-406222-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human PAPPA(NM_002581.3) - SHR087468 from Creative biogene

Category siRNA
Species Reactivities Human

Human PAPPA siRNA - orb263871 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PAPPA shRNA Plasmid (Human) - CHH3369 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PAPPA miRNA 3'UTR clone - MiUTR1H-07497 from Creative biogene

Species Reactivities Human
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