SIPA1

Gene Symbol SIPA1
Entrez Gene 6494
Alt Symbol SPA1
Species Human
Gene Type protein-coding
Description signal-induced proliferation-associated 1
Other Description GTPase-activating protein Spa-1|p130 SPA-1|signal-induced proliferation-associated gene 1|signal-induced proliferation-associated protein 1|sipa-1
Swissprots O60618 Q96FS4 O60484 O14518 Q2YD83
Accessions AAC32559 EAW74421 EAW74422 EAW74423 Q96FS4 AB005666 BAA22197 AF029789 AAC32547 AI307277 AK303551 BAG64575 AK308234 AK310068 BC010492 AAH10492 BC110353 AAI10354 BM677738 DN999403 XM_005274189 XP_005274246 XM_011545214 XP_011543516 XM_011545215 XP_011543517 XR_247210 XR_950017 NM_006747 NP_006738 NM_153253 NP_694985
Function GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:9346962}.
Subcellular Location Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region.
Tissue Specificity Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.
Top Pathways Leukocyte transendothelial migration, Rap1 signaling pathway

SPA-1 (E-6) - sc-166949 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SPA-1 (E-6): sc-166949. Western blot analysis of SPA-1 expression in non-transfected: sc-117752 (A) and mouse SPA-1 transfected: sc-123727 (B) 293T whole cell lysates.

SPA-1 (B-2) - sc-166914 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SPA-1 (B-2): sc-166914. Western blot analysis of SPA-1 expression in non-transfected: sc-117752 (A) and human SPA-1 transfected: sc-111824 (B) 293T whole cell lysates and CCRF-CEM nuclear extract (C).

SPA-1 (B-7) - sc-166219 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SPA-1 (C-1): sc-166219. Western blot analysis of SPA-1 expression in non-transfected: sc-117752 (A) and human SPA-1 transfected: sc-111824 (B) 293T whole cell lysates.

SPA-1 (B-3) - sc-137047 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SPA-1 (B-3): sc-137047. Western blot analysis of SPA-1 expression in non-transfected: sc-117752 (A) and human SPA-1 transfected: sc-111824 (B) 293T whole cell lysates.

SPA-1 (M-300) - sc-67095 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SPA-1 (M-300): sc-67095. Western blot analysis of SPA-1 expression in non-transfected: sc-117752 (A) and human SPA-1 transfected: sc-111824 (B) 293T whole cell lysates.

SPA-1 (C-1) - sc-137043 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SPA-1 (C-1): sc-137043. Western blot analysis of SPA-1 expression in non-transfected: sc-117752 (A) and human SPA-1 transfected: sc-111824 (B) 293T whole cell lysates.

SPA-1 (H-300) - sc-67094 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SPA-1 (H-300): sc-67094. Western blot analysis of SPA-1 expression in non-transfected 293: sc-110760 (A), human SPA-1 transfected 293: sc-112259 (B) and HeLa (C) whole cell lysates.

SPA-1 (E-20) - sc-23030 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SPA-1 (E-20): sc-23030. Western blot analysis of SPA-1 expression in non-transfected: sc-117752 (A) and mouse SPA-1 transfected: sc-111824 (B) 293T whole cell lysates.

SPA-1 (N-13) - sc-23028 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SPA-1 (N-13): sc-23028. Western blot analysis of SPA-1 expression in CCRF-CEM nuclear extract (A) and rat spleen (B) and mouse spleen (C) tissue extracts.

SPA-1 (3) - sc-136189 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
SPA-1 (3): sc-136189. Western blot analysis of SPA-1 expression in non-transfected: sc-117752 (A) and human SPA-1 transfected: sc-111824 (B) 293T whole cell lysates and CCRF-CEM nuclear extract (C).

Anti-SIPA1 antibody - ab85928 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of SIPA1 in Immunoprecipitates of whole cell lysate from HeLa cells (1 mg for IP, 20% of IP loaded), using ab85928 at 3 µg/mg lysate for IP and at 1 µg/ml for subsequent Western blot. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-SIPA1 antibody - ab10162 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SIPA1 antibody - ab130676 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SIPA1 antibody (ab130676) at 1/100 dilution + NCI-H292 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-SIPA1 antibody - ab124202 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SIPA1 antibody (ab124202) at 1 µg/ml + Human brain tissue lysate at 15 µg

Anti-SIPA1 antibody [EPR14134] - ab189929 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14134
All lanes : Anti-SIPA1 antibody [EPR14134] (ab189929) at 1/5000 dilutionLane 1 : Human fetal thymusLane 2 : Raji cell lysateLane 3 : 293T cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-SIPA1 antibody - C-terminal - ab198869 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling SIPA1 with ab198869 at 1/30 dilution.

Anti-SIPA1 antibody - C-terminal - ab155024 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SIPA1 antibody - C-terminal (ab155024) at 1/500 dilutionLane 1 : 293T cell lysate, non-transfectedLane 2 : 293T cell lysate, transfected with SIPA1

Anti-SIPA1 Antibody (clone 2B4) - LS-C198199 from LifeSpan Bioscience

Prices $355.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 2B4

Anti-SIPA1 Antibody (aa942-970, AP) - LS-C269454 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIPA1 Antibody (aa942-970, APC) - LS-C269455 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIPA1 Antibody (aa942-970, Biotin) - LS-C269456 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIPA1 Antibody (aa942-970, FITC) - LS-C269457 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIPA1 Antibody (aa942-970, Azide-free, HRP) - LS-C269458 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIPA1 Antibody (aa942-970, PE) - LS-C269459 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIPA1 Antibody (aa992-1042) - LS-C288785 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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