SIPA1
| Gene Symbol | SIPA1 |
|---|---|
| Entrez Gene | 6494 |
| Alt Symbol | SPA1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | signal-induced proliferation-associated 1 |
| Other Description | GTPase-activating protein Spa-1|p130 SPA-1|signal-induced proliferation-associated gene 1|signal-induced proliferation-associated protein 1|sipa-1 |
| Swissprots | O60618 Q96FS4 O60484 O14518 Q2YD83 |
| Accessions | AAC32559 EAW74421 EAW74422 EAW74423 Q96FS4 AB005666 BAA22197 AF029789 AAC32547 AI307277 AK303551 BAG64575 AK308234 AK310068 BC010492 AAH10492 BC110353 AAI10354 BM677738 DN999403 XM_005274189 XP_005274246 XM_011545214 XP_011543516 XM_011545215 XP_011543517 XR_247210 XR_950017 NM_006747 NP_006738 NM_153253 NP_694985 |
| Function | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:9346962}. |
| Subcellular Location | Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region. |
| Tissue Specificity | Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord. |
| Top Pathways | Leukocyte transendothelial migration, Rap1 signaling pathway |
SPA-1 CRISPR/Cas9 KO Plasmid (h) - sc-406755 from Santa Cruz Biotechnology
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SPA-1 HDR Plasmid (h) - sc-406755-HDR from Santa Cruz Biotechnology
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SPA-1 Double Nickase Plasmid (h) - sc-406755-NIC from Santa Cruz Biotechnology
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SPA-1 Double Nickase Plasmid (h2) - sc-406755-NIC-2 from Santa Cruz Biotechnology
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SPA-1 CRISPR Activation Plasmid (h) - sc-406755-ACT from Santa Cruz Biotechnology
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SPA-1 CRISPR Activation Plasmid (h2) - sc-406755-ACT-2 from Santa Cruz Biotechnology
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SPA-1 Lentiviral Activation Particles (h) - sc-406755-LAC from Santa Cruz Biotechnology
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SPA-1 Lentiviral Activation Particles (h2) - sc-406755-LAC-2 from Santa Cruz Biotechnology
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SPA-1 siRNA (h) - sc-45418 from Santa Cruz Biotechnology
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SPA-1 shRNA Plasmid (h) - sc-45418-SH from Santa Cruz Biotechnology
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SPA-1 shRNA (h) Lentiviral Particles - sc-45418-V from Santa Cruz Biotechnology
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SIPA1 RNAi - H00006494-R01 from Novus Biologicals
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SIPA1 RNAi - H00006494-R02 from Novus Biologicals
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MISSION® esiRNA - EHU220431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19350 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19350 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01171 from Sigma-Aldrich
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SIPA1 siRNA (Human) - CRH4390 from Cohesion Biosciences
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SIPA1 - MBS8219458 from MyBioSource
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shRNA set against Human SIPA1 (NM_006747.3) - SHH407644 from Creative biogene
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SPA-1 CRISPR/Cas9 KO Plasmid (h2) - sc-406755-KO-2 from Santa Cruz Biotechnology
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SPA-1 HDR Plasmid (h2) - sc-406755-HDR-2 from Santa Cruz Biotechnology
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SIPA1 shRNA Plasmid (Human) - CHH4390 from Cohesion Biosciences
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SIPA1 miRNA 3'UTR clone - MiUTR3H-04736 from Creative biogene
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SIPA1 miRNA 3'UTR clone - MiUTR3H-04737 from Creative biogene
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