| Gene Symbol |
SIPA1
|
| Entrez Gene |
6494
|
| Alt Symbol |
SPA1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
signal-induced proliferation-associated 1
|
| Other Description |
GTPase-activating protein Spa-1|p130 SPA-1|signal-induced proliferation-associated gene 1|signal-induced proliferation-associated protein 1|sipa-1
|
| Swissprots |
O60618 Q96FS4 O60484 O14518 Q2YD83
|
| Accessions |
AAC32559 EAW74421 EAW74422 EAW74423 Q96FS4 AB005666 BAA22197 AF029789 AAC32547 AI307277 AK303551 BAG64575 AK308234 AK310068 BC010492 AAH10492 BC110353 AAI10354 BM677738 DN999403 XM_005274189 XP_005274246 XM_011545214 XP_011543516 XM_011545215 XP_011543517 XR_247210 XR_950017 NM_006747 NP_006738 NM_153253 NP_694985
|
| Function |
GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:9346962}.
|
| Subcellular Location |
Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region.
|
| Tissue Specificity |
Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.
|
| Top Pathways |
Leukocyte transendothelial migration, Rap1 signaling pathway
|