BHLHE40

Gene Symbol	BHLHE40
Entrez Gene	8553
Alt Symbol	BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14
Species	Human
Gene Type	protein-coding
Description	basic helix-loop-helix family, member e40
Other Description	basic helix-loop-helix domain containing, class B, 2|class B basic helix-loop-helix protein 2|class E basic helix-loop-helix protein 40|differentially expressed in chondrocytes 1|differentially expressed in chondrocytes protein 1|differentiated embryo chondrocyte expressed gene 1|enhancer-of-split and hairy-related protein 2|stimulated by retinoic acid gene 13 protein
Swissprots	O14503 Q96TD3
Accessions	ABM64206 BAB18565 CBX47607 EAW63916 EAW63917 O14503 AA632164 AB004066 BAA21720 AK293205 BAG56745 AK309173 AK312509 BAG35410 BC068292 BC082238 AAH82238 BI962730 CR456921 CAG33202 DB144350 EU446668 ABZ92197 NM_003670 NP_003661
Function	Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway. {ECO:0000269|Pub
Subcellular Location	Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Predominantly localized in the nucleus.
Tissue Specificity	Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver, muscle and stomach.
Top Pathways	Circadian rhythm

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DEC1 (S-8) - sc-101023 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

DEC1 (H-87) - sc-135127 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-SHARP2 antibody - ab23797 from Abcam Prices $380.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SHARP2 antibody - ab97525 from Abcam Prices $304.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-SHARP2 antibody - ab70723 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SHARP2 antibody - ab135078 from Abcam Host Rabbit Clonality Polyclonal

Anti-SHARP2 antibody - ab56415 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-SHARP2 antibody - ab90594 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SHARP2 antibody - ab75327 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-BHLHB2 / DEC1 Antibody (aa36-51) - LS-C26259 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-BHLHB2 / DEC1 Antibody (aa249-298) - LS-C30309 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-BHLHB2 / DEC1 Antibody (C-Terminus, Biotin) - LS-C142758 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-BHLHB2 / DEC1 Antibody (C-Terminus, DY650) - LS-C142759 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-BHLHB2 / DEC1 Antibody (C-Terminus, DY488) - LS-C142760 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-BHLHB2 / DEC1 Antibody (C-Terminus, HRP) - LS-C142761 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-BHLHB2 / DEC1 Antibody (C-Terminus, DY550) - LS-C142762 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-BHLHB2 / DEC1 Antibody (C-Terminus) - LS-C144897 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-BHLHB2 / DEC1 Antibody (aa20-70) - LS-C148817 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BHLHB2 / DEC1 Antibody (aa29-59, APC) - LS-C252555 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BHLHB2 / DEC1 Antibody (aa22-51) - LS-C156812 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-BHLHB2 / DEC1 Antibody (aa29-59, AP) - LS-C252556 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BHLHB2 / DEC1 Antibody (aa29-59, FITC) - LS-C252557 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BHLHB2 / DEC1 Antibody (aa29-59, PE) - LS-C252558 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BHLHB2 / DEC1 Antibody (C-Terminus) IHC-plus™ - LS-B2222 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-BHLHB2 / DEC1 Antibody (aa130-230) - LS-C306541 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

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