BHLHE40

Gene Symbol BHLHE40
Entrez Gene 8553
Alt Symbol BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14
Species Human
Gene Type protein-coding
Description basic helix-loop-helix family, member e40
Other Description basic helix-loop-helix domain containing, class B, 2|class B basic helix-loop-helix protein 2|class E basic helix-loop-helix protein 40|differentially expressed in chondrocytes 1|differentially expressed in chondrocytes protein 1|differentiated embryo chondrocyte expressed gene 1|enhancer-of-split and hairy-related protein 2|stimulated by retinoic acid gene 13 protein
Swissprots O14503 Q96TD3
Accessions ABM64206 BAB18565 CBX47607 EAW63916 EAW63917 O14503 AA632164 AB004066 BAA21720 AK293205 BAG56745 AK309173 AK312509 BAG35410 BC068292 BC082238 AAH82238 BI962730 CR456921 CAG33202 DB144350 EU446668 ABZ92197 NM_003670 NP_003661
Function Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway. {ECO:0000269|Pub
Subcellular Location Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Predominantly localized in the nucleus.
Tissue Specificity Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver, muscle and stomach.
Top Pathways Circadian rhythm

Centromere protein X (STRA13), Human, ELISA Kit - E01C0945 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t
Sensitivity 0.1ng/ml
Range 0.5-10ng/ml

Centromere protein X (STRA13), Human, ELISA Kit - E01C2453 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Class E basic helix-loop-helix protein 40 (BHLHE40), Human, ELISA Kit - E01C0967 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Class E basic helix loop helix protein 40 (BHLHE40), ELISA Kit - MBS7238871 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Class E basic helix-loop-helix protein 40 (BHLHE40), ELISA Kit - MBS7222285 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Class E basic helix-loop-helix protein 40 (BHLHE40), ELISA Kit - MBS7201061 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Class E basic helix-loop-helix protein 40 (BHLHE40), ELISA Kit - MBS7244080 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Class E basic helix-loop-helix protein 40 (BHLHE40), ELISA Kit - MBS7236688 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Class E basic helix-loop-helix protein 40 (BHLHE40), ELISA Kit - MBS7251058 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Class E basic helix-loop-helix protein 40 (BHLHE40), ELISA Kit - MBS7221635 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Class E basic helix-loop-helix protein 40 (BHLHE40), ELISA Kit - MBS7228851 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Class E basic helix-loop-helix protein 40 (BHLHE40), ELISA Kit - MBS7253458 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Class E basic helix-loop-helix protein 40 (BHLHE40), ELISA Kit - MBS7211238 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Class E basic helix-loop-helix protein 40 (BHLHE40), ELISA Kit - MBS7236598 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Class E basic helix-loop-helix protein 40 (BHLHE40), ELISA Kit - MBS7201788 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human STRA13 ELISA Kit - E007795 from Biobool

Category ELISA Kit

Human BHLHE40 ELISA Kit - E009546 from Biobool

Category ELISA Kit

Human DEC1 ELISA Kit - E081055 from Biobool

Category ELISA Kit

Class E basic helix-loop-helix protein 40, ELISA Kit - MBS285974 from MyBioSource

Category ELISA Kit
Prices $465.00, $790.00, $3,500.00, $6,655.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Class E basic helix-loop-helix protein 40, ELISA Kit - MBS285472 from MyBioSource

Category ELISA Kit
Prices $465.00, $790.00, $3,500.00, $6,655.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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