BHLHE40

Gene Symbol	BHLHE40
Entrez Gene	8553
Alt Symbol	BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14
Species	Human
Gene Type	protein-coding
Description	basic helix-loop-helix family, member e40
Other Description	basic helix-loop-helix domain containing, class B, 2|class B basic helix-loop-helix protein 2|class E basic helix-loop-helix protein 40|differentially expressed in chondrocytes 1|differentially expressed in chondrocytes protein 1|differentiated embryo chondrocyte expressed gene 1|enhancer-of-split and hairy-related protein 2|stimulated by retinoic acid gene 13 protein
Swissprots	O14503 Q96TD3
Accessions	ABM64206 BAB18565 CBX47607 EAW63916 EAW63917 O14503 AA632164 AB004066 BAA21720 AK293205 BAG56745 AK309173 AK312509 BAG35410 BC068292 BC082238 AAH82238 BI962730 CR456921 CAG33202 DB144350 EU446668 ABZ92197 NM_003670 NP_003661
Function	Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway. {ECO:0000269|Pub
Subcellular Location	Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Predominantly localized in the nucleus.
Tissue Specificity	Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver, muscle and stomach.
Top Pathways	Circadian rhythm

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SHARP2 peptide - ab25843 from Abcam Category Peptide

Human SHARP2 protein fragment - ab152887 from Abcam Category Protein Source Wheat germ Species Human

BHLHB2 / DEC1 Antibody Blocking Peptide - LS-E371 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STRA13 Antibody Blocking Peptide - LS-E19016 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DEC1 Partial Recombinant Protein - H00008553-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

BHLHE40-Antibody-N-term-Blocking-Peptide - BP10647a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

STRA13 Blocking Peptide - 33R-5917 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

BHLHB2 / BHLHE40 - H00008553-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BHLHB2 / BHLHE40 - H00008553-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

BHLHE40 fusion protein - Ag12236 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, T-HIS Species Human

Recombinant Human BHLHE40, His-tagged - BHLHE40-10221H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Class E basic helix-loop-helix protein 40(BHLHE40) - CSB-YP002691HU CSB-EP002691HU CSB-BP002691HU CSB-MP002691HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

BHLHB2 / BHLHE40 - TP310294 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

DEC1 Recombinant Protein Antigen - NBP2-47488PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

STRA13 Protein - NBP1-84760PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

BHLHE40 Peptide, Human - M34GP01432H from Creative Peptides Category Peptide Source Synthetic. Species Human

DEC1 Peptide, Human - M34GP04174H from Creative Peptides Category Peptide Source Synthetic. Species Human

Class E basic helix-loop-helix protein 40 (BHLHE40), Recombinant Protein - MBS1048558 from MyBioSource Category Protein Prices $1,185.00, $1,185.00, $1,405.00, $1,405.00, $1,910.00, $1,910.00, $2,370.00, $2,370.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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