BHLHE40

Gene Symbol BHLHE40
Entrez Gene 8553
Alt Symbol BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14
Species Human
Gene Type protein-coding
Description basic helix-loop-helix family, member e40
Other Description basic helix-loop-helix domain containing, class B, 2|class B basic helix-loop-helix protein 2|class E basic helix-loop-helix protein 40|differentially expressed in chondrocytes 1|differentially expressed in chondrocytes protein 1|differentiated embryo chondrocyte expressed gene 1|enhancer-of-split and hairy-related protein 2|stimulated by retinoic acid gene 13 protein
Swissprots O14503 Q96TD3
Accessions ABM64206 BAB18565 CBX47607 EAW63916 EAW63917 O14503 AA632164 AB004066 BAA21720 AK293205 BAG56745 AK309173 AK312509 BAG35410 BC068292 BC082238 AAH82238 BI962730 CR456921 CAG33202 DB144350 EU446668 ABZ92197 NM_003670 NP_003661
Function Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway. {ECO:0000269|Pub
Subcellular Location Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Predominantly localized in the nucleus.
Tissue Specificity Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver, muscle and stomach.
Top Pathways Circadian rhythm

DEC1 CRISPR/Cas9 KO Plasmid (h) - sc-402058 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DEC1 HDR Plasmid (h) - sc-402058-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DEC1 Double Nickase Plasmid (h) - sc-402058-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DEC1 Double Nickase Plasmid (h2) - sc-402058-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DEC1 CRISPR Activation Plasmid (h) - sc-402058-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DEC1 CRISPR Activation Plasmid (h2) - sc-402058-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DEC1 Lentiviral Activation Particles (h) - sc-402058-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DEC1 Lentiviral Activation Particles (h2) - sc-402058-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DEC1 siRNA (h) - sc-106769 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DEC1 shRNA Plasmid (h) - sc-106769-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DEC1 shRNA (h) Lentiviral Particles - sc-106769-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DEC1 RNAi - H00008553-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU015061 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3969 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3969 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09753 from Sigma-Aldrich

Category miRNA

BHLHE40 siRNA (Human) - CRH5622 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BHLHE40 - MBS8212655 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human BHLHE40 (NM_003670.2) - SHH246606 from Creative biogene

Category siRNA
Species Reactivities Human

Human BHLHE40 siRNA - orb266124 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BHLHE40 shRNA Plasmid (Human) - CHH5622 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

BHLHE40 miRNA 3'UTR clone - MiUTR3H-06678 from Creative biogene

Species Reactivities Human
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