TNRC6A
| Gene Symbol | TNRC6A |
|---|---|
| Entrez Gene | 27327 |
| Alt Symbol | CAGH26, GW1, GW182, TNRC6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | trinucleotide repeat containing 6A |
| Other Description | CAG repeat protein 26|EDIE|EMSY interactor protein|GW182 autoantigen|glycine-tryptophan protein of 182 kDa|trinucleotide repeat-containing gene 6A protein |
| Swissprots | Q9NV59 Q8NDV7 Q9P268 Q658L5 O15408 Q8TCR0 Q8TBT8 Q6NVB5 C9JAR8 Q8NEZ0 |
| Accessions | EAW55782 EAW55783 EAW55784 EAW55785 EAW55786 EAW55787 Q8NDV7 AB040893 BAA95984 AJ492221 CAD37348 AK001773 BAA91899 AK025277 AK025696 AK094542 BAG52884 AK299905 BAG61746 AL713750 CAD28525 AL833757 CAH56236 AY035864 AAK62026 BC024324 AAH24324 BC068209 BC172409 AAI72409 BE158958 BU743266 U23860 U80739 AAB91438 XM_005255254 XP_005255311 XM_005255257 XP_005255314 XM_006721039 XP_006721102 XM_011545791 XP_011544093 XM_011545792 XP_011544094 XM_011545793 XP_011544095 XM_011545794 XP_011544096 XM_011545795 XP_011544097 XM_011545796 XP_011544098 NM_014494 NP_055309 |
| Function | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA- dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}. |
| Subcellular Location | Cytoplasm, P-body {ECO:0000269|PubMed:11950943, ECO:0000269|PubMed:13130130, ECO:0000269|PubMed:15494374, ECO:0000269|PubMed:15908945, ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:18946079, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19324964}. Note=Mammalian P-bodies are also known as GW bodies (GWBs). |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:11950943}. |
GW182 CRISPR/Cas9 KO Plasmid (h) - sc-400906 from Santa Cruz Biotechnology
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GW182 HDR Plasmid (h) - sc-400906-HDR from Santa Cruz Biotechnology
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GW182 Double Nickase Plasmid (h) - sc-400906-NIC from Santa Cruz Biotechnology
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GW182 Double Nickase Plasmid (h2) - sc-400906-NIC-2 from Santa Cruz Biotechnology
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GW182 CRISPR Activation Plasmid (h) - sc-400906-ACT from Santa Cruz Biotechnology
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GW182 CRISPR Activation Plasmid (h2) - sc-400906-ACT-2 from Santa Cruz Biotechnology
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GW182 Lentiviral Activation Particles (h) - sc-400906-LAC from Santa Cruz Biotechnology
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GW182 Lentiviral Activation Particles (h2) - sc-400906-LAC-2 from Santa Cruz Biotechnology
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GW182 siRNA (h) - sc-45516 from Santa Cruz Biotechnology
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GW182 shRNA Plasmid (h) - sc-45516-SH from Santa Cruz Biotechnology
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GW182 shRNA (h) Lentiviral Particles - sc-45516-V from Santa Cruz Biotechnology
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GW182 RNAi - H00027327-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN21798 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21798 from Sigma-Aldrich
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TNRC6A siRNA (Human) - CRH9078 from Cohesion Biosciences
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GW182 RNAi - H00027327-R02 from Novus Biologicals
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TNRC6A - MBS8220818 from MyBioSource
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GW182 CRISPR/Cas9 KO Plasmid (h2) - sc-400906-KO-2 from Santa Cruz Biotechnology
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GW182 HDR Plasmid (h2) - sc-400906-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human TNRC6A (NM_014494.2) - SHH432536 from Creative biogene
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shRNA set against Human TNRC6A(NM_014494.2) - SHL086736 from Creative biogene
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TNRC6A shRNA Plasmid (Human) - CHH9078 from Cohesion Biosciences
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TNRC6A miRNA 3'UTR clone - MiUTR1H-10631 from Creative biogene
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