| Gene Symbol | GPX7 |
|---|---|
| Entrez Gene | 2882 |
| Alt Symbol | CL683, GPX6, GPx-7, GSHPx-7, NPGPx |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutathione peroxidase 7 |
| Other Description | glutathione peroxidase 6|non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase |
| Swissprots | Q96SL4 O95337 Q5T501 |
| Accessions | AAY88741 EAX06777 Q96SL4 AF091092 AAC72961 AF320068 AAN76501 AK027683 BAB55294 AY358402 AAQ88768 BC032788 AAH32788 BI550170 BU627166 DQ894018 ABM84944 NM_015696 NP_056511 |
| Function | It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. {ECO:0000269|PubMed:22157330}. |
| Subcellular Location | Secreted {ECO:0000305}. |
| Tissue Specificity | Expressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids. {ECO:0000269|PubMed:22157330}. |
| Top Pathways | Thyroid hormone synthesis, Glutathione metabolism, Arachidonic acid metabolism |