Gene Symbol | GPX7 |
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Entrez Gene | 2882 |
Alt Symbol | CL683, GPX6, GPx-7, GSHPx-7, NPGPx |
Species | Human |
Gene Type | protein-coding |
Description | glutathione peroxidase 7 |
Other Description | glutathione peroxidase 6|non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase |
Swissprots | Q96SL4 O95337 Q5T501 |
Accessions | AAY88741 EAX06777 Q96SL4 AF091092 AAC72961 AF320068 AAN76501 AK027683 BAB55294 AY358402 AAQ88768 BC032788 AAH32788 BI550170 BU627166 DQ894018 ABM84944 NM_015696 NP_056511 |
Function | It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. {ECO:0000269|PubMed:22157330}. |
Subcellular Location | Secreted {ECO:0000305}. |
Tissue Specificity | Expressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids. {ECO:0000269|PubMed:22157330}. |
Top Pathways | Thyroid hormone synthesis, Glutathione metabolism, Arachidonic acid metabolism |
GPx-7 CRISPR/Cas9 KO Plasmid (h) - sc-404694 from Santa Cruz Biotechnology
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GPx-7 HDR Plasmid (h) - sc-404694-HDR from Santa Cruz Biotechnology
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GPx-7 Double Nickase Plasmid (h) - sc-404694-NIC from Santa Cruz Biotechnology
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GPx-7 Double Nickase Plasmid (h2) - sc-404694-NIC-2 from Santa Cruz Biotechnology
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GPx-7 CRISPR Activation Plasmid (h) - sc-404694-ACT from Santa Cruz Biotechnology
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GPx-7 CRISPR Activation Plasmid (h2) - sc-404694-ACT-2 from Santa Cruz Biotechnology
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GPx-7 Lentiviral Activation Particles (h) - sc-404694-LAC from Santa Cruz Biotechnology
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GPx-7 Lentiviral Activation Particles (h2) - sc-404694-LAC-2 from Santa Cruz Biotechnology
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GPx-7 siRNA (h) - sc-78832 from Santa Cruz Biotechnology
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GPx-7 shRNA Plasmid (h) - sc-78832-SH from Santa Cruz Biotechnology
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GPx-7 shRNA (h) Lentiviral Particles - sc-78832-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU149381 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9651 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04895 from Sigma-Aldrich
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GPX7 siRNA (Human) - CRH1938 from Cohesion Biosciences
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GPX7 - MBS8235845 from MyBioSource
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shRNA set against Human GPX7 (NM_015696.4) - SHH307430 from Creative biogene
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GPX7 shRNA Plasmid (Human) - CHH1938 from Cohesion Biosciences
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GPX7 miRNA 3'UTR clone - MiUTR3H-15014 from Creative biogene
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