| Gene Symbol |
GPX7
|
| Entrez Gene |
2882
|
| Alt Symbol |
CL683, GPX6, GPx-7, GSHPx-7, NPGPx
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glutathione peroxidase 7
|
| Other Description |
glutathione peroxidase 6|non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase
|
| Swissprots |
Q96SL4 O95337 Q5T501
|
| Accessions |
AAY88741 EAX06777 Q96SL4 AF091092 AAC72961 AF320068 AAN76501 AK027683 BAB55294 AY358402 AAQ88768 BC032788 AAH32788 BI550170 BU627166 DQ894018 ABM84944 NM_015696 NP_056511
|
| Function |
It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. {ECO:0000269|PubMed:22157330}.
|
| Subcellular Location |
Secreted {ECO:0000305}.
|
| Tissue Specificity |
Expressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids. {ECO:0000269|PubMed:22157330}.
|
| Top Pathways |
Thyroid hormone synthesis, Glutathione metabolism, Arachidonic acid metabolism
|