| Gene Symbol |
PTPRN
|
| Entrez Gene |
5798
|
| Alt Symbol |
IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein tyrosine phosphatase, receptor type, N
|
| Other Description |
ICA 512|PTP IA-2|islet cell antigen 2|islet cell antigen 512|islet cell autoantigen 3|protein tyrosine phosphatase-like N|receptor-type tyrosine-protein phosphatase-like N
|
| Swissprots |
Q53QD6 Q08319 B4DK12 Q6NSL1 F5GZS3 Q16849
|
| Accessions |
AAY24038 EAW70724 EAW70725 EAW70726 Q16849 AB209368 BAD92605 AK054765 AK122679 BAG53662 AK291469 BAF84158 AK294490 BAG57712 AK296335 BAG59024 AK314574 BC007713 AAH07713 BC070053 AAH70053 BT006975 AAP35621 DC344431 DC352946 L18983 AAA90974 X62899 CAA44688 XM_011511566 XP_011509868 NM_001199763 NP_001186692 NM_001199764 NP_001186693 NM_002846 NP_002837
|
| Function |
Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. {ECO:0000269|PubMed:8144912, ECO:0000269|PubMed:8641276}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein. Note=Neuroendocrine secretory granules.
|
| Tissue Specificity |
Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary. {ECO:0000269|PubMed:8024693}.
|
| Top Pathways |
Type I diabetes mellitus
|
