PTPRN
| Gene Symbol | PTPRN |
|---|---|
| Entrez Gene | 5798 |
| Alt Symbol | IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein tyrosine phosphatase, receptor type, N |
| Other Description | ICA 512|PTP IA-2|islet cell antigen 2|islet cell antigen 512|islet cell autoantigen 3|protein tyrosine phosphatase-like N|receptor-type tyrosine-protein phosphatase-like N |
| Swissprots | Q53QD6 Q08319 B4DK12 Q6NSL1 F5GZS3 Q16849 |
| Accessions | AAY24038 EAW70724 EAW70725 EAW70726 Q16849 AB209368 BAD92605 AK054765 AK122679 BAG53662 AK291469 BAF84158 AK294490 BAG57712 AK296335 BAG59024 AK314574 BC007713 AAH07713 BC070053 AAH70053 BT006975 AAP35621 DC344431 DC352946 L18983 AAA90974 X62899 CAA44688 XM_011511566 XP_011509868 NM_001199763 NP_001186692 NM_001199764 NP_001186693 NM_002846 NP_002837 |
| Function | Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. {ECO:0000269|PubMed:8144912, ECO:0000269|PubMed:8641276}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. Note=Neuroendocrine secretory granules. |
| Tissue Specificity | Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary. {ECO:0000269|PubMed:8024693}. |
| Top Pathways | Type I diabetes mellitus |
Human PTPIA2 / PTPRN full length protein - ab42590 from Abcam
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Human PTPIA2 / PTPRN peptide - ab24481 from Abcam
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PTPRN / IA-2 Antibody Blocking Peptide - LS-E3350 from LifeSpan Bioscience
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Recombinant Human IA-2/PTPRN Protein - H00005798-Q01 from Novus Biologicals
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IA-2/PTPRN Peptide - P3261 from Novus Biologicals
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PTPRN-Antibody-Center-Blocking-Peptide - BP14523c from Abgent, a WuXi AppTec company
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PTPIA2-Antibody-N-term-Blocking-Peptide - BP8428a from Abgent, a WuXi AppTec company
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IA2 blocking peptide - GTX88611-PEP from GeneTex
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PTPRN Blocking Peptide - 33R-2806 from Fitzgerald
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Human PTPRN Protein - abx068777 from Abbexa
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PTPIA2 / PTPRN Peptide - AC21-1495-P from Abcore
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PTPRN - H00005798-Q01-10 from Acris Antibodies
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PTPRN - H00005798-Q01-25 from Acris Antibodies
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PTPRN Peptide - 42-745P from ProSci
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PTPRN fusion protein - Ag17909 from Proteintech Group
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PTPRN fusion protein - Ag0923 from Proteintech Group
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PTPIA2(PTPRN), Active Human Recombinant Protein - GWB-5T9WX1 from Genway Biotech
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Recombinant Human PTPRN protein, DDK-tagged - PTPRN-256H from Creative Biomart
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Recombinant Human PTPRN protein, His-tagged - PTPRN-258H from Creative Biomart
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Recombinant Human PTPRN, His-tagged - PTPRN-2064H from Creative Biomart
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Recombinant Human PTPRN - PTPRN-559H from Creative Biomart
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Recombinant Human PTPRN, GST-tagged - PTPRN-457H from Creative Biomart
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Recombinant Human Protein Tyrosine Phosphatase, Receptor Type, N, GST-tagged - PTPRN-1307H from Creative Biomart
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Recombinant Protein Tyrosine Phosphatase Receptor Type N (PTPRN) - RPA954Hu01 from Uscn Life Science Inc.
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Recombinant Protein Tyrosine Phosphatase Receptor Type N (PTPRN) - RPA954Hu02 from Uscn Life Science Inc.
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