| Gene Symbol |
RAD51AP1
|
| Entrez Gene |
10635
|
| Alt Symbol |
PIR51
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAD51 associated protein 1
|
| Other Description |
RAD51-associated protein 1|RAD51-interacting protein
|
| Swissprots |
Q7Z779 A8K7D3 O43403 Q96B01
|
| Accessions |
EAW88843 EAW88844 Q96B01 AF006259 AAC39554 AK096930 BAC04902 AK290428 BAF83117 AK291948 BAF84637 AK300773 BAG62437 AK309706 AK316367 BAH14738 AL832243 BC005973 BC006992 AAH06992 BC016330 AAH16330 BU689445 DC397655 HQ447239 ADQ31726 JF432673 ADZ15890 XM_011520911 XP_011519213 NM_001130862 NP_001124334 NM_006479 NP_006470
|
| Function |
May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA. {ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:9396801}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Note=Colocalizes with RAD51 to multiple nuclear foci. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in testis and thymus. Lower levels in colon and small intestine. Little or no expression in spleen, prostate, ovary and peripheral blood leukocytes. {ECO:0000269|PubMed:9396801}.
|