Gene Symbol | TFPI |
---|---|
Entrez Gene | 7035 |
Alt Symbol | EPI, LACI, TFI, TFPI1 |
Species | Human |
Gene Type | protein-coding |
Description | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
Other Description | anti-convertin|extrinsic pathway inhibitor|tissue factor pathway inhibitor |
Swissprots | P10646 Q53TS4 O95103 |
Accessions | AAA59480 AAA59526 AAO89075 AAY14807 EAX10921 EAX10922 EAX10923 P10646 AB209866 BAD93103 AF021834 AAD01700 AK130306 AK313562 BAG36336 AU136083 BC014332 BC015514 AAH15514 CA418214 HQ447091 ADQ31578 J03225 AAA52022 XM_005246818 XP_005246875 XM_005246819 XP_005246876 XM_005246820 XP_005246877 XM_006712720 XP_006712783 XM_011511707 XP_011510009 XM_011511708 XP_011510010 XM_011511709 XP_011510011 NM_001032281 NP_001027452 NM_006287 NP_006278 |
Function | Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. |
Subcellular Location | Isoform Alpha: Secreted. |
Tissue Specificity | Mostly in endothelial cells. |
Top Pathways | Complement and coagulation cascades |