UNC119

Gene Symbol UNC119
Entrez Gene 9094
Alt Symbol HRG4, IMD13, POC7, POC7A
Species Human
Gene Type protein-coding
Description unc-119 homolog (C. elegans)
Other Description POC7 centriolar protein homolog A|protein unc-119 homolog A|retinal protein 4
Swissprots O95126 A8K8G4 Q13432 F1T095
Accessions AAD31422 EAW51093 EAW51094 EAW51095 EAW51096 EAW51097 EAW51098 Q13432 AB593014 BAJ83969 AF028788 AAD01875 AF028789 AAD01876 AK124531 BAG54049 AK292329 BAF85018 BC027176 AAH27176 BM848267 BX641031 CAE46019 BX647747 BX648530 U40998 AAC50360 XM_011525459 XP_011523761 NM_005148 NP_005139 NM_054035 NP_473376
Function Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid- binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A. {ECO:0000269|PubMed:12496276, ECO:0000269|PubMed:14757743, ECO:0000269|PubMed:19381274, ECO:0000269|PubMed:21642972, ECO:0000269|PubMed:22085962, ECO:0000269|PubMed:23535298, ECO:0000305|PubMed:22960633}.
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23535298}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:23535298}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23535298}. Note=Localizes to the centrosome in interphase cells and begins to translocate from the spindle pole to the spindle midzone after the onset of mitosis; it then localizes to the intercellular bridge in telophase cells and to the midbody in cytokinetic cells. {ECO:0000269|PubMed:23535298}.
Tissue Specificity Abundantly expressed in retina, in photoreceptor synapses and inner segments. Expressed in a much lesser extent in several other tissues. {ECO:0000269|PubMed:9761287}.

HRG4 (H-58) - sc-367624 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HRG4 (H-58): sc-367624. Western blot analysis of HRG4 expression in mouse testis (A) and mouse spleen (B) tissue extracts.

HRG4 (L-17) - sc-82931 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HRG4 (L-17): sc-82931. Western blot analysis of HRG4 expression in mouse eye tissue extract.

Anti-Retinal protein 4 antibody - ab103277 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-Retinal protein 4 antibody (ab103277) at 1/50 dilution + Mouse testis tissue lysate at 35 µg

Anti-Retinal protein 4 antibody - ab56047 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UNC119 / Retinal Protein 4 Antibody (aa64-94) - LS-C160431 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human testis tissue reacted with UNC119 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

UNC119 Antibody - H00009094-B01P-50ug from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: UNC119 Antibody [H00009094-B01P-50ug] - Expression in transfected 293T cell line. Lane 1: UNC119 transfected lysate(26.4 KDa). Lane 2: Non-transfected lysate.

UNC119 Antibody - NBP1-81708 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: UNC119 Antibody [NBP1-81708] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

UNC119 Antibody - NBP1-46269 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

UNC119 Antibody - NBP2-20811 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: UNC119 Antibody [NBP2-20811] - Sample (30 ug of whole cell lysate) A: HeLa 12% SDS PAGE gel, diluted at 1:1000.

UNC119 Antibody (2F9-2A9) - H00009094-M01 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F9-2A9
Western Blot: UNC119 Antibody (2F9-2A9) [H00009094-M01] - Analysis of UNC119 expression in transfected 293T cell line by UNC119 monoclonal antibody (M01), clone 2F9-2A9.Lane 1: UNC119 transfected lysate(27 KDa).Lane 2: Non-transfected lysate.

UNC119 Antibody (2F9-2A9) - H00009094-M01A from Novus Biologicals

Prices $349.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 2F9-2A9

Monoclonal Anti-UNC119 antibody produced in mouse - SAB1404669 from Sigma-Aldrich

Prices $347.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 2F9-2A9
<B>Immunoblotting</B><BR/>Monoclonal Anti-UNC119: <B>Cat. No. SAB1404669</B>: Antibody concentration: 1 μg/mL. Specific band of ~52.5 kDa using immunogen protein lysate.

Anti-UNC119 (206-220) antibody produced in rabbit - SAB1105423 from Sigma-Aldrich

Prices $279.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Monoclonal Anti-UNC119 antibody produced in mouse - WH0009094M1 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2F9-2A9
<B>Immunoblotting</B><BR/>Monoclonal Anti-UNC119, <B>Cat. No. WH0009094M1</B> used at the antibody concentration: 1 μg/mL. Specific band of ~52.14 kDa using immunogen protein lysate.

Anti-UNC119 (54-65) antibody produced in rabbit - SAB1105422 from Sigma-Aldrich

Prices $279.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC119 antibody produced in rabbit - HPA041912 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-UNC119: <B>Cat. No. HPA041912</B>: Immunohistochemical staining of human prostate shows moderate granular cytoplasmic positivity in subset of glandular cells.

UNC119-Antibody-Center - AP9373c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of UNC119 Antibody (Center) (Cat. #AP9373c) in mouse testis tissue lysates (35ug/lane). UNC119 (arrow) was detected using the purified Pab.

UNC119-Antibody-monoclonal-M01 - AT4469a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F9-2A9
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (52.14 KDa) .

UNC119 Antibody - middle region (OAAB05964) - OAAB05964 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

UNC119 antibody - 13065-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of MDCK cells using 13065-1-AP( UNC119 Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

UNC119 (Center) antibody - AP54459PU-N from Acris Antibodies

Prices $330.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human testis tissue reacted with RS18 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

UNC119 antibody - H00009094-B01P from Acris Antibodies

Prices $360.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

UNC119 antibody - H00009094-D01 from Acris Antibodies

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot analysis of UNC119 expression in transfected 293T cell line (H00009094-T02) by UNC119 MaxPab polyclonal antibody. Lane 1: UNC119 transfected lysate(27.00 KDa). Lane 2: Non-transfected lysate.

UNC119 antibody - H00009094-M01 from Acris Antibodies

Prices $360.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F9-2A9
Western Blot analysis of UNC119 expression in transfected 293T cell line by UNC119 monoclonal antibody (M01), clone 2F9-2A9.Lane 1: UNC119 transfected lysate(27 KDa).Lane 2: Non-transfected lysate.

UNC119 antibody - H00009094-M01A from Acris Antibodies

Prices $360.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 2F9-2A9
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