UNC119
| Gene Symbol | UNC119 |
|---|---|
| Entrez Gene | 9094 |
| Alt Symbol | HRG4, IMD13, POC7, POC7A |
| Species | Human |
| Gene Type | protein-coding |
| Description | unc-119 homolog (C. elegans) |
| Other Description | POC7 centriolar protein homolog A|protein unc-119 homolog A|retinal protein 4 |
| Swissprots | O95126 A8K8G4 Q13432 F1T095 |
| Accessions | AAD31422 EAW51093 EAW51094 EAW51095 EAW51096 EAW51097 EAW51098 Q13432 AB593014 BAJ83969 AF028788 AAD01875 AF028789 AAD01876 AK124531 BAG54049 AK292329 BAF85018 BC027176 AAH27176 BM848267 BX641031 CAE46019 BX647747 BX648530 U40998 AAC50360 XM_011525459 XP_011523761 NM_005148 NP_005139 NM_054035 NP_473376 |
| Function | Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid- binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A. {ECO:0000269|PubMed:12496276, ECO:0000269|PubMed:14757743, ECO:0000269|PubMed:19381274, ECO:0000269|PubMed:21642972, ECO:0000269|PubMed:22085962, ECO:0000269|PubMed:23535298, ECO:0000305|PubMed:22960633}. |
| Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23535298}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:23535298}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23535298}. Note=Localizes to the centrosome in interphase cells and begins to translocate from the spindle pole to the spindle midzone after the onset of mitosis; it then localizes to the intercellular bridge in telophase cells and to the midbody in cytokinetic cells. {ECO:0000269|PubMed:23535298}. |
| Tissue Specificity | Abundantly expressed in retina, in photoreceptor synapses and inner segments. Expressed in a much lesser extent in several other tissues. {ECO:0000269|PubMed:9761287}. |
HRG4 CRISPR/Cas9 KO Plasmid (h) - sc-406218 from Santa Cruz Biotechnology
|
||||||||
HRG4 HDR Plasmid (h) - sc-406218-HDR from Santa Cruz Biotechnology
|
||||||||
HRG4 Double Nickase Plasmid (h) - sc-406218-NIC from Santa Cruz Biotechnology
|
||||||||
HRG4 Double Nickase Plasmid (h2) - sc-406218-NIC-2 from Santa Cruz Biotechnology
|
||||||||
HRG4 CRISPR Activation Plasmid (h) - sc-406218-ACT from Santa Cruz Biotechnology
|
||||||||
HRG4 CRISPR Activation Plasmid (h2) - sc-406218-ACT-2 from Santa Cruz Biotechnology
|
||||||||
HRG4 Lentiviral Activation Particles (h) - sc-406218-LAC from Santa Cruz Biotechnology
|
||||||||
HRG4 Lentiviral Activation Particles (h2) - sc-406218-LAC-2 from Santa Cruz Biotechnology
|
||||||||
HRG4 siRNA (h) - sc-75299 from Santa Cruz Biotechnology
|
||||||||
HRG4 shRNA Plasmid (h) - sc-75299-SH from Santa Cruz Biotechnology
|
||||||||
HRG4 shRNA (h) Lentiviral Particles - sc-75299-V from Santa Cruz Biotechnology
|
||||||||
UNC119 RNAi - H00009094-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU093211 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN22491 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22491 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR07242 from Sigma-Aldrich
|
||||||||
UNC119 siRNA (Human) - CRH6007 from Cohesion Biosciences
|
||||||||
UNC119 RNAi - H00009094-R01 from Novus Biologicals
|
||||||||
UNC119 - MBS8229363 from MyBioSource
|
||||||||
shRNA set against Human UNC119 (NM_005148.3) - SHH440452 from Creative biogene
|
||||||||
Human UNC119 siRNA - orb266509 from Biorbyt
|
||||||||
UNC119 shRNA Plasmid (Human) - CHH6007 from Cohesion Biosciences
|
||||||||
UNC119 miRNA 3'UTR clone - MiUTR3H-06435 from Creative biogene
|
||||||||
UNC119 miRNA 3'UTR clone - MiUTR3H-06436 from Creative biogene
|