UNC119

Gene Symbol	UNC119
Entrez Gene	9094
Alt Symbol	HRG4, IMD13, POC7, POC7A
Species	Human
Gene Type	protein-coding
Description	unc-119 homolog (C. elegans)
Other Description	POC7 centriolar protein homolog A|protein unc-119 homolog A|retinal protein 4
Swissprots	O95126 A8K8G4 Q13432 F1T095
Accessions	AAD31422 EAW51093 EAW51094 EAW51095 EAW51096 EAW51097 EAW51098 Q13432 AB593014 BAJ83969 AF028788 AAD01875 AF028789 AAD01876 AK124531 BAG54049 AK292329 BAF85018 BC027176 AAH27176 BM848267 BX641031 CAE46019 BX647747 BX648530 U40998 AAC50360 XM_011525459 XP_011523761 NM_005148 NP_005139 NM_054035 NP_473376
Function	Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid- binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A. {ECO:0000269|PubMed:12496276, ECO:0000269|PubMed:14757743, ECO:0000269|PubMed:19381274, ECO:0000269|PubMed:21642972, ECO:0000269|PubMed:22085962, ECO:0000269|PubMed:23535298, ECO:0000305|PubMed:22960633}.
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23535298}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:23535298}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23535298}. Note=Localizes to the centrosome in interphase cells and begins to translocate from the spindle pole to the spindle midzone after the onset of mitosis; it then localizes to the intercellular bridge in telophase cells and to the midbody in cytokinetic cells. {ECO:0000269|PubMed:23535298}.
Tissue Specificity	Abundantly expressed in retina, in photoreceptor synapses and inner segments. Expressed in a much lesser extent in several other tissues. {ECO:0000269|PubMed:9761287}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Retinal protein 4 full length protein - ab160338 from Abcam Category Protein Source Wheat germ Species Human

UNC119 / Retinal Protein 4 Antibody Blocking Peptide - LS-E10091 from LifeSpan Bioscience Category Protein Prices $145.00 Sizes 100 µg

Recombinant Human UNC119 Protein - H00009094-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

UNC119-Antibody-Center-Blocking-Peptide - BP9373c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UNC119 - H00009094-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UNC119 - H00009094-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

UNC119 fusion protein - ag3757 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Human NRG4 Protein - 12183-HNCE-20 from Sino Biological Category Protein Prices $138.00, $298.00 Sizes 20 µg, 50 µg Source E. coli Species Human

Recombinant Neuregulin 4 (NRG4) - RPC174Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Protein unc-119 homolog A(UNC119) - CSB-YP622658HU CSB-EP622658HU CSB-BP622658HU CSB-MP622658HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Protein unc-119(unc-119) - CSB-YP615031CXX CSB-EP615031CXX CSB-BP615031CXX CSB-MP615031CXX from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Caenorhabditis

UNC119 (transcript variant 1) - TP303758 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

UNC119 (transcript variant 2) - TP312513 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Homo sapiens (Human) Protein unc-119 homolog A - CSB-EP622658HU from Cusabio Category Protein Species Human

UNC119 Protein - NBP1-81708PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

UNC119 Peptide, Human - M34GP17083H from Creative Peptides Category Peptide Source Synthetic. Species Human

UNC119 Recombinant Protein (OPCA03599) - OPCA03599 from Aviva Systems Biology Category Protein Prices $365.00 Sizes 50 µg Source Human

Human UNC119 protein - orb358865 from Biorbyt Category Protein Prices $306.00, $383.00, $944.00, $1,564.00, $2,474.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

Recombinant Human Protein unc-119 homolog A(UNC119) - AP74422 from Signalway Antibody Category Protein Prices $155.00, $390.00, $665.00, $1,090.00, $1,835.00, $2,915.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Protein unc-119 (unc-119), Recombinant Protein - MBS1313379 from MyBioSource Category Protein Prices $970.00, $970.00, $1,190.00, $1,190.00, $1,455.00, $1,455.00, $1,920.00, $1,920.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Caenorhabditis

Recombinant Human UNC119 Protein (1-240 aa), His-SUMO-tagged - UNC119-1990H from Creative Biomart Category Protein Source E. coli Species Human

Search more