| Gene Symbol |
UNC119
|
| Entrez Gene |
9094
|
| Alt Symbol |
HRG4, IMD13, POC7, POC7A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
unc-119 homolog (C. elegans)
|
| Other Description |
POC7 centriolar protein homolog A|protein unc-119 homolog A|retinal protein 4
|
| Swissprots |
O95126 A8K8G4 Q13432 F1T095
|
| Accessions |
AAD31422 EAW51093 EAW51094 EAW51095 EAW51096 EAW51097 EAW51098 Q13432 AB593014 BAJ83969 AF028788 AAD01875 AF028789 AAD01876 AK124531 BAG54049 AK292329 BAF85018 BC027176 AAH27176 BM848267 BX641031 CAE46019 BX647747 BX648530 U40998 AAC50360 XM_011525459 XP_011523761 NM_005148 NP_005139 NM_054035 NP_473376
|
| Function |
Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid- binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A. {ECO:0000269|PubMed:12496276, ECO:0000269|PubMed:14757743, ECO:0000269|PubMed:19381274, ECO:0000269|PubMed:21642972, ECO:0000269|PubMed:22085962, ECO:0000269|PubMed:23535298, ECO:0000305|PubMed:22960633}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23535298}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:23535298}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23535298}. Note=Localizes to the centrosome in interphase cells and begins to translocate from the spindle pole to the spindle midzone after the onset of mitosis; it then localizes to the intercellular bridge in telophase cells and to the midbody in cytokinetic cells. {ECO:0000269|PubMed:23535298}.
|
| Tissue Specificity |
Abundantly expressed in retina, in photoreceptor synapses and inner segments. Expressed in a much lesser extent in several other tissues. {ECO:0000269|PubMed:9761287}.
|