| Gene Symbol |
SF3A3
|
| Entrez Gene |
10946
|
| Alt Symbol |
PRP9, PRPF9, SAP61, SF3a60
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
splicing factor 3a, subunit 3, 60kDa
|
| Other Description |
SAP 61|pre-mRNA splicing factor SF3a (60kD)|spliceosome associated protein 61|spliceosome-associated protein 61|splicing factor 3A subunit 3|splicing factor 3a, subunit 3, 60kD
|
| Swissprots |
D3DPT5 Q5VT87 Q12874 Q15460
|
| Accessions |
EAX07304 EAX07305 EAX07306 Q12874 AI492088 AK026887 AK128438 BAG54674 AK222554 BAD96274 AK291181 BAF83870 AK292116 BAF84805 AK301424 BAG62952 BC002395 AAH02395 BC011523 AAH11523 BM702776 BM905122 CA443595 DQ891120 ABM82046 EU176559 ABW03360 N67022 N91991 U08815 AAA19625 XM_005270390 XP_005270447 NM_006802 NP_006793
|
| Function |
Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
|
| Subcellular Location |
Nucleus speckle.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Spliceosome
|