Gene Symbol | SF3A3 |
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Entrez Gene | 10946 |
Alt Symbol | PRP9, PRPF9, SAP61, SF3a60 |
Species | Human |
Gene Type | protein-coding |
Description | splicing factor 3a, subunit 3, 60kDa |
Other Description | SAP 61|pre-mRNA splicing factor SF3a (60kD)|spliceosome associated protein 61|spliceosome-associated protein 61|splicing factor 3A subunit 3|splicing factor 3a, subunit 3, 60kD |
Swissprots | D3DPT5 Q5VT87 Q12874 Q15460 |
Accessions | EAX07304 EAX07305 EAX07306 Q12874 AI492088 AK026887 AK128438 BAG54674 AK222554 BAD96274 AK291181 BAF83870 AK292116 BAF84805 AK301424 BAG62952 BC002395 AAH02395 BC011523 AAH11523 BM702776 BM905122 CA443595 DQ891120 ABM82046 EU176559 ABW03360 N67022 N91991 U08815 AAA19625 XM_005270390 XP_005270447 NM_006802 NP_006793 |
Function | Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. |
Subcellular Location | Nucleus speckle. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Spliceosome |
SAP 61 CRISPR/Cas9 KO Plasmid (h) - sc-408469 from Santa Cruz Biotechnology
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SAP 61 HDR Plasmid (h) - sc-408469-HDR from Santa Cruz Biotechnology
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SAP 61 Double Nickase Plasmid (h) - sc-408469-NIC from Santa Cruz Biotechnology
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SAP 61 Double Nickase Plasmid (h2) - sc-408469-NIC-2 from Santa Cruz Biotechnology
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SAP 61 CRISPR Activation Plasmid (h) - sc-408469-ACT from Santa Cruz Biotechnology
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SAP 61 CRISPR Activation Plasmid (h2) - sc-408469-ACT-2 from Santa Cruz Biotechnology
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SAP 61 Lentiviral Activation Particles (h) - sc-408469-LAC from Santa Cruz Biotechnology
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SAP 61 Lentiviral Activation Particles (h2) - sc-408469-LAC-2 from Santa Cruz Biotechnology
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SAP 61 siRNA (h) - sc-76443 from Santa Cruz Biotechnology
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SAP 61 shRNA Plasmid (h) - sc-76443-SH from Santa Cruz Biotechnology
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SAP 61 shRNA (h) Lentiviral Particles - sc-76443-V from Santa Cruz Biotechnology
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SF3A3 RNAi - H00010946-R01 from Novus Biologicals
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MISSION® esiRNA - EHU111931 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19184 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19184 from Sigma-Aldrich
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SF3A3 siRNA (Human) - CRH7468 from Cohesion Biosciences
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SF3A3 - MBS8206317 from MyBioSource
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shRNA set against Human Sf3a3 (NM_006802.2) - SHH405796 from Creative biogene
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shRNA set against Human SF3A3(NM_006802.2) - SHR218918 from Creative biogene
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Human SF3A3 siRNA - orb267970 from Biorbyt
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SF3A3 shRNA Plasmid (Human) - CHH7468 from Cohesion Biosciences
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SF3A3 miRNA 3'UTR clone - MiUTR1H-09322 from Creative biogene
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