RCHY1

Gene Symbol	RCHY1
Entrez Gene	25898
Alt Symbol	ARNIP, CHIMP, PIRH2, PRO1996, RNF199, ZCHY, ZNF363
Species	Human
Gene Type	protein-coding
Description	ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
Other Description	CH-rich interacting match with PLAG1|E3 ubiquitin-protein ligase Pirh2|RING finger and CHY zinc finger domain-containing protein 1|RING finger protein 199|androgen-receptor N-terminal-interacting protein|p53-induced protein with a RING-H2 domain|zinc finger protein 363|zinc finger, CHY-type
Swissprots	J3KPI0 C7E543 C7E541 E7ETW5 Q2KN33 Q59GN7 D3YRV2 B3KRG3 Q86X26 Q96PM5 Q96PR5 C7E542 E7EMC8
Accessions	EAX05724 EAX05725 EAX05726 EAX05727 EAX05728 Q96PM5 AB209072 BAD92309 AF247041 AAL76101 AF255666 AAK96896 AF305424 AAL09356 AK091501 BAG52375 AK308754 AK308848 AK309555 AL050144 CAB43290 AW236209 AY888047 AAX78233 BC015464 AAH15464 BC031057 BC047393 AAH47393 BF102905 BG703058 BI913695 BP314571 BQ024871 BQ959587 CB241669 CF597260 DA197338 DB044826 DN919417 GQ129342 ACT64476 GQ129343 ACT64477 GQ250944 ACT35531 GQ250945 ACT35532 GQ250946 ACT35533 GU937000 ADD21555 HQ447979 ADQ32462 JF691538 AEO00252 JF691539 AEO00253 XM_011531838 XP_011530140 XM_011531839 XP_011530141 NM_001009922 NP_001009922 NM_001278536 NP_001265465 NM_001278537 NP_001265466 NM_001278538 NP_001265467 NM_001278539 NP_001265468 NM_015436 NP_056251 NR_037913 NR_037914 NR_103723 NR_103724 NR_103725 NM_001008925
Function	Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity. {ECO:0000269|PubMed:16914734, ECO:0000269|PubMed:17721809, ECO:0000269|PubMed:18006823, ECO:0000269|PubMed:19043414, ECO:0000269|PubMed:19483087, ECO:0000269|PubMed:21791603, ECO:0000269|PubMed:21994467}.
Subcellular Location	Nucleus. Nucleus speckle. Cytoplasm.
Top Pathways	p53 signaling pathway, Ubiquitin mediated proteolysis, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Pirh2 full length protein - ab161829 from Abcam Category Protein Source Wheat germ Species Human

Human Pirh2 full length protein - ab167827 from Abcam Category Protein Source E. coli Species Human

Human Pirh2 protein fragment - ab161830 from Abcam Category Protein Source Wheat germ Species Human

RCHY1 / PIRH2 Antibody Blocking Peptide - LS-E15814 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Pirh2 Partial Recombinant Protein - H00025898-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Pirh2 Recombinant Protein - H00025898-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Pirh2 Protein - NBP2-23438 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Source E.coli Species Human

RCHY1-Antibody-N-term-H44-Blocking-Peptide - BP2796a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RCHY1 Blocking Peptide - 33R-4551 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RCHY1 protein (His tag) - 80R-2892 from Fitzgerald Category Protein Prices $365.00 Sizes 100 µg Source E.coli

RCHY1 / PIRH2 (1-261, His-tag) - AR51011PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 500 µg Source E. coli Species Human

RCHY1 / PIRH2 (1-261, His-tag) - AR51011PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

RCHY1 / PIRH2 - H00025898-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RCHY1 / PIRH2 - H00025898-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RCHY1 / PIRH2 - H00025898-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RCHY1 / PIRH2 - H00025898-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RCHY1, 1-261aa, Human, His tag, E.coli - 01-P2187 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

RCHY1 fusion protein - ag4916 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

RCHY1 fusion protein - ag4942 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase, His-tagged - RCHY1-233H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human RING finger and CHY zinc finger domain-containing protein 1(RC - CSB-YP822281HU CSB-EP822281HU CSB-BP822281HU CSB-MP822281HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RCHY1, 1-261aa, Human, His tag, E.coli (Denatured) - ATGP2187 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 20 µg, 100 µg, 500 µg Species Human

RCHY1 Protein - abx164159 from Abbexa Category Protein Species Human, Mouse, Rat

RCHY1 / PIRH2 (transcript variant 1) - TP307970 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Human RCHY1 protein - orb260056 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

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