Gene Symbol | NDST2 |
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Entrez Gene | 8509 |
Alt Symbol | HSST2, NST2 |
Species | Human |
Gene Type | protein-coding |
Description | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 |
Other Description | N-HSST 2|N-heparan sulfate sulfotransferase 2|NDST-2|bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2|glucosaminyl N-deacetylase/N-sulfotransferase 2 |
Swissprots | Q59H89 Q2TB32 P52849 |
Accessions | AAB97086 EAW54525 EAW54526 P52849 AB208870 BAD92107 AK293527 BAG57009 AK298957 BAG61053 AK300520 BAG62232 AK301251 BAG62818 AK303648 BAG64651 AK310580 BC018681 BC035711 AAH35711 BC110588 AAI10589 BC110589 AAI10590 U36601 AAC27120 XM_005270255 XP_005270312 XM_005270256 XP_005270313 XM_006718046 XP_006718109 XM_011540310 XP_011538612 XR_945852 NM_003635 NP_003626 |
Function | Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. {ECO:0000269|PubMed:10758005, ECO:0000269|PubMed:12634318, ECO:0000269|PubMed:16343444}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Top Pathways | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
NDST2 (D-20) - sc-16764 from Santa Cruz Biotechnology
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Anti-NDST2 antibody - ab151141 from Abcam
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Anti-NDST2 antibody - C-terminal - ab175522 from Abcam
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Anti-NDST2 antibody - N-terminal - ab191613 from Abcam
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Anti-NDST2 Antibody (aa817-844, AP) - LS-C264142 from LifeSpan Bioscience
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Anti-NDST2 Antibody (aa817-844, APC) - LS-C264143 from LifeSpan Bioscience
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Anti-NDST2 Antibody (aa817-844, Biotin) - LS-C264144 from LifeSpan Bioscience
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Anti-NDST2 Antibody (aa817-844, FITC) - LS-C264145 from LifeSpan Bioscience
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Anti-NDST2 Antibody (aa817-844, Azide-free, HRP) - LS-C264146 from LifeSpan Bioscience
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Anti-NDST2 Antibody (aa817-844, PE) - LS-C264148 from LifeSpan Bioscience
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Anti-NDST2 Antibody (aa824-853) - LS-C323264 from LifeSpan Bioscience
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Anti-NDST2 Antibody (aa817-844) - LS-C164793 from LifeSpan Bioscience
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Anti-NDST2 Antibody (aa505-554) - LS-C201491 from LifeSpan Bioscience
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Anti-NDST2 Antibody (N-Terminus) IHC-plus⢠- LS-B12161 from LifeSpan Bioscience
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N-Deacetylase/N-Sulfotransferase 2/NDST2 Antibody - NBP2-13645 from Novus Biologicals
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ANTI-NDST2 (C-TERM) antibody produced in rabbit - SAB1302656 from Sigma-Aldrich
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NDST2 Antibody - C-terminal region (ARP45486_P050) - ARP45486_P050 from Aviva Systems Biology
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NDST2 Antibody - C-terminal region (OAAB03166) - OAAB03166 from Aviva Systems Biology
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NDST2-Antibody-C-term - AP5759b from Abgent, a WuXi AppTec company
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NDST2 Antibody - 7869 from ProSci
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NDST2 antibody - 13716-1-AP from Proteintech Group
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Anti-NDST2 (aa 755-815) polyclonal antibody - DPABH-03302 from Creative Diagnostics
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Anti-NDST2 (aa 824-853) polyclonal antibody - DPABH-11632 from Creative Diagnostics
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Anti-NDST2 (aa 628-677) polyclonal antibody - DPABH-13839 from Creative Diagnostics
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NDST2 Polyclonal Antibody - PA5-25662 from Thermo Fisher Scientific
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