| Gene Symbol |
NDST2
|
| Entrez Gene |
8509
|
| Alt Symbol |
HSST2, NST2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
|
| Other Description |
N-HSST 2|N-heparan sulfate sulfotransferase 2|NDST-2|bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2|glucosaminyl N-deacetylase/N-sulfotransferase 2
|
| Swissprots |
Q59H89 Q2TB32 P52849
|
| Accessions |
AAB97086 EAW54525 EAW54526 P52849 AB208870 BAD92107 AK293527 BAG57009 AK298957 BAG61053 AK300520 BAG62232 AK301251 BAG62818 AK303648 BAG64651 AK310580 BC018681 BC035711 AAH35711 BC110588 AAI10589 BC110589 AAI10590 U36601 AAC27120 XM_005270255 XP_005270312 XM_005270256 XP_005270313 XM_006718046 XP_006718109 XM_011540310 XP_011538612 XR_945852 NM_003635 NP_003626
|
| Function |
Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. {ECO:0000269|PubMed:10758005, ECO:0000269|PubMed:12634318, ECO:0000269|PubMed:16343444}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
|