| Gene Symbol |
LEO1
|
| Entrez Gene |
123169
|
| Alt Symbol |
RDL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
|
| Other Description |
RNA polymerase-associated protein LEO1|replicative senescence down-regulated leo1-like protein
|
| Swissprots |
Q96N99 Q8WVC0
|
| Accessions |
EAW77432 EAW77433 Q8WVC0 AK055762 BAB71006 AK297972 BAG60282 AY302186 AAP68819 BC018147 AAH18147 XM_011521211 XP_011519513 NM_001286430 NP_001273359 NM_138792 NP_620147
|
| Function |
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15791002}.
|
| Tissue Specificity |
Highly expressed in skeletal muscle and heart. Weakly expressed in placenta and liver. {ECO:0000269|PubMed:15791002}.
|