LEO1

Gene Symbol	LEO1
Entrez Gene	123169
Alt Symbol	RDL
Species	Human
Gene Type	protein-coding
Description	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Other Description	RNA polymerase-associated protein LEO1|replicative senescence down-regulated leo1-like protein
Swissprots	Q96N99 Q8WVC0
Accessions	EAW77432 EAW77433 Q8WVC0 AK055762 BAB71006 AK297972 BAG60282 AY302186 AAP68819 BC018147 AAH18147 XM_011521211 XP_011519513 NM_001286430 NP_001273359 NM_138792 NP_620147
Function	Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex
Subcellular Location	Nucleus {ECO:0000269|PubMed:15791002}.
Tissue Specificity	Highly expressed in skeletal muscle and heart. Weakly expressed in placenta and liver. {ECO:0000269|PubMed:15791002}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LEO1 full length protein - ab132311 from Abcam Category Protein Source Wheat germ Species Human

Human LEO1 peptide - ab27737 from Abcam Category Peptide

LEO1 Antibody Blocking Peptide - LS-E6783 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LEO1 Antibody Blocking Peptide - LS-E7421 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LEO1 Antibody Blocking Peptide - LS-E7427 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LEO1 Antibody Blocking Peptide - LS-E18949 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human LEO1 Protein - H00123169-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

LEO1 Peptide - P1693 from Novus Biologicals Category Peptide Species Human

LEO1-Antibody-N-term-Blocking-Peptide - BP1978a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-LEO1S10-Antibody-Blocking-peptide - BP3581a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-Leo1S551-Antibody-Blocking-peptide - BP3564a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

LEO1 - H00123169-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

LEO1 - H00123169-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

LEO1 fusion protein - ag2932 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human RNA polymerase-associated protein LEO1(LEO1) - CSB-YP845150HU CSB-EP845150HU CSB-BP845150HU CSB-MP845150HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

LEO1 - TP302274 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

LEO1 Protein - NBP1-89423PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

LEO1 Recombinant Protein Antigen - NBP1-86236PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

LEO1-Antibody-S551-Blocking-Peptide - BP1978e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LEO1-Antibody-S205-Blocking-Peptide - BP1978d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Leo1-S151-Blocking-Peptide-N-term - BP1978h from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Leo1-S10-Blocking-Peptide-N-term - BP1978g from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Leo1-S171-Blocking-Peptide-N-term - BP1978f from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LEO1 Peptide, Human - M34GP08639H from Creative Peptides Category Peptide Source Synthetic. Species Human

RNA polymerase-associated protein LEO1 (LEO1), Recombinant Protein - MBS1428746 from MyBioSource Category Protein Prices $1,465.00, $1,465.00, $1,695.00, $1,695.00, $2,495.00, $2,495.00, $2,940.00, $2,940.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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