LEO1

Gene Symbol LEO1
Entrez Gene 123169
Alt Symbol RDL
Species Human
Gene Type protein-coding
Description Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Other Description RNA polymerase-associated protein LEO1|replicative senescence down-regulated leo1-like protein
Swissprots Q96N99 Q8WVC0
Accessions EAW77432 EAW77433 Q8WVC0 AK055762 BAB71006 AK297972 BAG60282 AY302186 AAP68819 BC018147 AAH18147 XM_011521211 XP_011519513 NM_001286430 NP_001273359 NM_138792 NP_620147
Function Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex
Subcellular Location Nucleus {ECO:0000269|PubMed:15791002}.
Tissue Specificity Highly expressed in skeletal muscle and heart. Weakly expressed in placenta and liver. {ECO:0000269|PubMed:15791002}.

LEO1 CRISPR/Cas9 KO Plasmid (h) - sc-407864 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LEO1 HDR Plasmid (h) - sc-407864-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LEO1 Double Nickase Plasmid (h) - sc-407864-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LEO1 Double Nickase Plasmid (h2) - sc-407864-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LEO1 CRISPR Activation Plasmid (h) - sc-407864-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LEO1 CRISPR Activation Plasmid (h2) - sc-407864-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LEO1 Lentiviral Activation Particles (h) - sc-407864-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LEO1 Lentiviral Activation Particles (h2) - sc-407864-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LEO1 siRNA (h) - sc-90032 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LEO1 shRNA Plasmid (h) - sc-90032-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LEO1 shRNA (h) Lentiviral Particles - sc-90032-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU073451 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11647 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11647 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

LEO1 siRNA (Human) - CRJ4726 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LEO1 (NM_138792.2) - SHH329595 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human LEO1(NM_138792.2) - SHH146287 from Creative biogene

Category siRNA
Species Reactivities Human

LEO1 shRNA Plasmid (Human) - CHJ4726 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LEO1 miRNA 3'UTR clone - MiUTR1H-05636 from Creative biogene

Species Reactivities Human
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