LEO1

Gene Symbol LEO1
Entrez Gene 123169
Alt Symbol RDL
Species Human
Gene Type protein-coding
Description Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Other Description RNA polymerase-associated protein LEO1|replicative senescence down-regulated leo1-like protein
Swissprots Q96N99 Q8WVC0
Accessions EAW77432 EAW77433 Q8WVC0 AK055762 BAB71006 AK297972 BAG60282 AY302186 AAP68819 BC018147 AAH18147 XM_011521211 XP_011519513 NM_001286430 NP_001273359 NM_138792 NP_620147
Function Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex
Subcellular Location Nucleus {ECO:0000269|PubMed:15791002}.
Tissue Specificity Highly expressed in skeletal muscle and heart. Weakly expressed in placenta and liver. {ECO:0000269|PubMed:15791002}.

LEO1 (G-18) - sc-324031 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LEO1 (N-17) - sc-324029 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LEO1 (N-17): sc-324029. Western blot analysis of LEO1 expression in Hep G2 whole cell lysate.

Anti-LEO1 antibody - ab33157 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-LEO1 antibody (ab33157) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-LEO1 antibody - ab43770 from Abcam

Prices $359.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-LEO1 antibody (ab43770) at 1/1000 dilutionLane 1 : Total protein extract from E coli with ~50ng to 100ng of GST fusion protein of an irrelevant antigenLane 2 : Total protein extract from E coli with ~50ng to 500ng of the antigen (GST-antigen fusion protein)Lysates/proteins at 20 µg per lane.SecondaryRabbit anti-mouse IgG + IgM, (H+L) conjugated to Horseradish peroxidase at 1/5000 dilution

Anti-LEO1 antibody - ab70630 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LEO1 antibody - ab103562 from Abcam

Prices $410.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab103562, at 1/100 dilution, staining LEO1 in formalin-fixed, paraffin-embedded Human stomach adenocarcinoma tissue by Immunohistochemistry using DAB staining.

Anti-LEO1 antibody - N-terminal - ab75721 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-LEO1 antibody - N-terminal (ab75721) at 1/50 dilution + HL60 cell line lysate at 35 µg

Anti-LEO1 Antibody (N-Terminus) - LS-C327749 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LEO1 Antibody (phospho-Ser10) - LS-C327751 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LEO1 Antibody (phospho-Ser551) - LS-C327750 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LEO1 Antibody (aa550-600) - LS-C287100 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse LEO1 by Immunohistochemistry. Sample: FFPE section of human stomach carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti-LEO1 used at a dilution of 1:5000 (0.2and 1:1000 (1 Detection: DAB.

Anti-LEO1 Antibody (aa550-600) - LS-C286786 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Mouse Leo1 by Immunohistochemistry. Sample: FFPE section of mouse colon carcinoma CT26. Antibody: Affinity purified rabbit anti-Leo1 used at a dilution of 1:100. Epitope Retrieval Buffer-High pH (IHC-101J) was substituted for Epitope Retrieval Buffer-Reduced pH.

Anti-LEO1 Antibody (phospho-Ser551) - LS-C97084 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Dot blot of anti-Phospho-Leo1-pS551 Antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

Anti-LEO1 Antibody (N-Terminus, APC) - LS-C206686 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LEO1 Antibody (N-Terminus, AP) - LS-C206687 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LEO1 Antibody (N-Terminus, Biotin) - LS-C206688 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LEO1 Antibody (N-Terminus, FITC) - LS-C206689 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LEO1 Antibody (N-Terminus, PE) - LS-C206690 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LEO1 Antibody (N-Terminus) - LS-C146517 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
LEO1 antibody LS-C146517 Western blot of Mouse Kidney lysate. Antibody concentration 1 ug/ml.

Anti-LEO1 Antibody (phospho-Ser551, Biotin) - LS-C206693 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LEO1 Antibody (phospho-Ser551, FITC) - LS-C206692 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LEO1 Antibody (aa550-600) IHC-plus™ - LS-B5697 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-LEO1 antibody IHC of human colon, epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5697 concentration 5 ug/ml.

Anti-LEO1 Antibody (phospho-Ser551, APC) - LS-C206694 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LEO1 Antibody (phospho-Ser551, AP) - LS-C206691 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LEO1 Antibody (phospho-Ser10) IHC-plus™ - LS-B4804 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-LEO1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4804 concentration 5 ug/ml.
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