CPE

Gene Symbol CPE
Entrez Gene 1363
Alt Symbol -
Species Human
Gene Type protein-coding
Description carboxypeptidase E
Other Description CPH|carboxypeptidase H|cobalt-stimulated chromaffin granule carboxypeptidase|enkephalin convertase|insulin granule-associated carboxypeptidase|prohormone-processing carboxypeptidase
Swissprots Q9UIU9 P16870 D3DP33 A8K4N1 B4DFN4 B3KR42
Accessions BAA86053 EAX04817 EAX04818 EAX04819 P16870 AI340177 AK090962 BAG52254 AK127165 BAG54445 AK290996 BAF83685 AK294175 BAG57495 BC033866 AAH33866 BC053612 AAH53612 BM271829 DQ893322 ABM84248 DQ896637 ABM87636 X51405 CAA35767 NM_001873 NP_001864
Function Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
Subcellular Location Isoform 1: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. {ECO:0000250}.
Tissue Specificity Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas. {ECO:0000269|PubMed:21285511}.
Top Pathways Type I diabetes mellitus

CPE (35) - sc-136252 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
CPE (35): sc-136252. Western blot analysis of CPE expression in rat brain tissue extract.

CPE (H-6) - sc-393760 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CPE (H-6): sc-393760. Western blot analysis of CPE expression in non-transfected: sc-117752 (A) and human CPE transfected: sc-116451 (B) 293T whole cell lysates.

CPE (H-5) - sc-393761 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CPE (H-5): sc-393761. Western blot analysis of CPE expression in non-transfected: sc-117752 (A) and human CPE transfected: sc-116451 (B) 293T whole cell lysates.

CPE (W-12) - sc-34321 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CPE (W-12): sc-34321. Western blot analysis of CPE expression in PC-12 whole cell lysate.

Anti-Carboxypeptidase H antibody - ab186724 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab186724. Blue DAPI for nuclear staining.

Anti-Carboxypeptidase H antibody - ab136009 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Carboxypeptidase H antibody (ab136009) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-Carboxypeptidase e / CPE Antibody (C-Terminus) - LS-C21230 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Carboxypeptidase e / CPE Antibody (N-Terminus) - LS-C21231 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Carboxypeptidase e / CPE Antibody (aa42-453) - LS-C35273 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal

Anti-Carboxypeptidase e / CPE Antibody - LS-C42694 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Carboxypeptidase e / CPE Antibody (C-Terminus) - LS-C42695 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Carboxypeptidase e / CPE Antibody (aa42-453) - LS-C77722 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-Carboxypeptidase e / CPE Antibody (Asp305) - LS-C192117 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Carboxypeptidase e / CPE Antibody (aa256-305) - LS-C291829 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Carboxypeptidase e / CPE Antibody (aa318-476, Biotin) - LS-C298049 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Carboxypeptidase e / CPE Antibody (aa318-476, FITC) - LS-C301824 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Carboxypeptidase e / CPE Antibody (aa318-476) - LS-C293163 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of recombinant Carboxypeptidase E / CPE.

Anti-Carboxypeptidase e / CPE Antibody (aa151-317) - LS-C293165 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of recombinant Carboxypeptidase E / CPE.

Anti-Carboxypeptidase e / CPE Antibody (C-Terminus) - LS-C97564 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of CPE antibody in HeLa cell line lysates (35 ug/lane). CPE (arrow) was detected using the purified antibody.

Anti-Carboxypeptidase e / CPE Antibody - LS-C335573 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded rat brain using CPE antibody at dilution of 1:200 (x400 lens).

Anti-Carboxypeptidase e / CPE Antibody (aa271-320) IHC-plus™ - LS-B9256 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-Carboxypeptidase E / CPE antibody IHC staining of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-Carboxypeptidase e / CPE Antibody (C-Terminus) IHC-plus™ - LS-B9448 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-Carboxypeptidase E / CPE antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-Carboxypeptidase e / CPE Antibody (aa36-85) IHC-plus™ - LS-B6638 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CPE antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6638 concentration 5 ug/ml.

Carboxypeptidase E/CPE Antibody [Unconjugated] - AF3587 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal

Carboxypeptidase E/CPE Antibody (420709) - MAB3587 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 420709
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