| Gene Symbol |
CPE
|
| Entrez Gene |
1363
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
carboxypeptidase E
|
| Other Description |
CPH|carboxypeptidase H|cobalt-stimulated chromaffin granule carboxypeptidase|enkephalin convertase|insulin granule-associated carboxypeptidase|prohormone-processing carboxypeptidase
|
| Swissprots |
Q9UIU9 P16870 D3DP33 A8K4N1 B4DFN4 B3KR42
|
| Accessions |
BAA86053 EAX04817 EAX04818 EAX04819 P16870 AI340177 AK090962 BAG52254 AK127165 BAG54445 AK290996 BAF83685 AK294175 BAG57495 BC033866 AAH33866 BC053612 AAH53612 BM271829 DQ893322 ABM84248 DQ896637 ABM87636 X51405 CAA35767 NM_001873 NP_001864
|
| Function |
Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
|
| Subcellular Location |
Isoform 1: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. {ECO:0000250}.
|
| Tissue Specificity |
Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas. {ECO:0000269|PubMed:21285511}.
|
| Top Pathways |
Type I diabetes mellitus
|
