| Gene Symbol |
HTR1A
|
| Entrez Gene |
3350
|
| Alt Symbol |
5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
|
| Other Description |
5-HT1a receptor|5-hydroxytryptamine receptor 1A|guanine nucleotide-binding regulatory protein-coupled receptor
|
| Swissprots |
Q6LAE7 P08908
|
| Accessions |
AAA36440 AAA66493 BAA94488 CAA31908 CAA40962 CAA77560 CAH03197 EAW51377 P08908 AF498978 AAM21125 AK291429 BAF84118 AK314187 BC069159 AAH69159 BC136263 AAI36264 DA160783 DA223047 DA527925 S64045 AAD13945 NM_000524 NP_000515
|
| Function |
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:22957
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8393041}; Multi-pass membrane protein {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8393041}.
|
| Tissue Specificity |
Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells. {ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:8393041}.
|
| Top Pathways |
cAMP signaling pathway, Neuroactive ligand-receptor interaction
|