HTR1A

Gene Symbol HTR1A
Entrez Gene 3350
Alt Symbol 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD
Species Human
Gene Type protein-coding
Description 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
Other Description 5-HT1a receptor|5-hydroxytryptamine receptor 1A|guanine nucleotide-binding regulatory protein-coupled receptor
Swissprots Q6LAE7 P08908
Accessions AAA36440 AAA66493 BAA94488 CAA31908 CAA40962 CAA77560 CAH03197 EAW51377 P08908 AF498978 AAM21125 AK291429 BAF84118 AK314187 BC069159 AAH69159 BC136263 AAI36264 DA160783 DA223047 DA527925 S64045 AAD13945 NM_000524 NP_000515
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:22957
Subcellular Location Cell membrane {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8393041}; Multi-pass membrane protein {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8393041}.
Tissue Specificity Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells. {ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:8393041}.
Top Pathways cAMP signaling pathway, Neuroactive ligand-receptor interaction

5-HTR1A Antibody - 9879 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with human Serotonin Receptor 1A/5-HTR1A (+), using 5-HTR1A Antibody.

SR-1A (H-119) - sc-10801 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SR-1A (H-119): sc-10801. Western blot analysis of glycosylated SR-1A expression in Saos-2 (A), Daudi (B) and Raji (C) whole cell lysates.

SR-1A (G-13) - sc-32549 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SR-1A (T-16) - sc-32548 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SR-1A (T-16): sc-32548. Western blot analysis of SR-1A expression in Caco-2 whole cell lysate.

SR-1A (C-19) - sc-1459 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SR-1A (C-19): sc-1459. Western blot analysis of SR-1A expression in Caco-2 whole cell lysate.

SR-1A (A-13) - sc-32550 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SR-1A (L-24) - sc-134034 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
SR-1A (L-24): sc-134034. Western blot analysis of glycosylated SR-1A expression in Daudi (A) and Raji (B) whole cell lysates.

Anti-5HT1A Receptor antibody - ab79230 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-5HT1A Receptor antibody (ab79230) at 1 µg/ml + Brain (Human) Tissue Lysate - adult normal tissue (ab29466) at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-5HT1A Receptor antibody - ab44635 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-5HT1A Receptor antibody (ab44635) at 1/500 dilution + Brain (Human) Tissue Lysate - adult normal tissue (ab29466) at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.Observed band size : 52 kDa (why is the actual band size different from the predicted?)Exposure time : 16 minutes

Anti-5HT1A Receptor antibody - ab101914 from Abcam

Prices $370.00
Sizes 100 µl
Host Goat
Clonality Polyclonal

Anti-5HT1A Receptor antibody - ab121032 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-5HT1A Receptor antibody (ab121032) at 1 µg/ml + Mouse brain lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-5HT1A Receptor antibody - ab64994 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-5HT1A Receptor antibody (ab64994) at 1/500 dilutionLane 1 : Extracts from HepG2 cells with no immunising peptideLane 2 : Extracts from Jurkat cells with no immunising peptideLane 3 : Extracts from Jurkat cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-5HT1A Receptor antibody - ab121027 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal

Anti-HTR1A / 5-HT1A Receptor Antibody (clone 19A9.2) IHC-plus™ - LS-B6043 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 19A9.2
Anti-5HT1A Receptor antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6043 concentration 10 ug/ml.

Anti-HTR1A / 5-HT1A Receptor Antibody (aa239-273) - LS-C344612 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of lysate from human brain tissue lysate with HTR1A Antibody. Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35 ug.

Anti-HTR1A / 5-HT1A Receptor Antibody (aa404-422) - LS-C312804 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HTR1A / 5-HT1A Receptor antibody. IHC(P): Rat Brain Tissue.

Anti-HTR1A / 5-HT1A Receptor Antibody (aa294-312) - LS-C39050 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR1A / 5-HT1A Receptor Antibody (Internal) - LS-C152813 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR1A / 5-HT1A Receptor Antibody (aa249-262) - LS-C154851 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-HTR1A / 5-HT1A Receptor Antibody (N-Terminus) - LS-C31005 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Daudi Cell Lysate, B: Raji Cell Lysate

Anti-HTR1A / 5-HT1A Receptor Antibody (Internal) - LS-C145170 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR1A / 5-HT1A Receptor Antibody (aa291-340) - LS-C119365 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HepG2/Jurkat cells, using 5-HT-1A Antibody. The lane on the right is treated with the synthesized peptide.

Anti-HTR1A / 5-HT1A Receptor Antibody (aa322-334) - LS-C154852 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
HTR1A antibody (1 ug/ml) staining of Mouse Brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-HTR1A / 5-HT1A Receptor Antibody (N-Terminus) IHC-plus™ - LS-B970 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-5HT1A Receptor antibody IHC of human brain, cortex, white matter. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B970 concentration 5 ug/ml.

Anti-HTR1A / 5-HT1A Receptor Antibody (Phe321) - LS-C176848 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of SR-1A (F321) pAb in paraffin-embedded human brain tissue.
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