HTR1A

Gene Symbol	HTR1A
Entrez Gene	3350
Alt Symbol	5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD
Species	Human
Gene Type	protein-coding
Description	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
Other Description	5-HT1a receptor|5-hydroxytryptamine receptor 1A|guanine nucleotide-binding regulatory protein-coupled receptor
Swissprots	Q6LAE7 P08908
Accessions	AAA36440 AAA66493 BAA94488 CAA31908 CAA40962 CAA77560 CAH03197 EAW51377 P08908 AF498978 AAM21125 AK291429 BAF84118 AK314187 BC069159 AAH69159 BC136263 AAI36264 DA160783 DA223047 DA527925 S64045 AAD13945 NM_000524 NP_000515
Function	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:22957
Subcellular Location	Cell membrane {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8393041}; Multi-pass membrane protein {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8393041}.
Tissue Specificity	Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells. {ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:8393041}.
Top Pathways	cAMP signaling pathway, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

5HT1A Receptor peptide - ab172416 from Abcam Category Peptide

5HT1A Receptor peptide (228-240) - ab45743 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human 5HT1A Receptor full length protein - ab132419 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human 5HT1A Receptor protein fragment - ab152462 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Rat 5HT1A Receptor peptide - ab98259 from Abcam Category Peptide

HTR1A / 5-HT1A Receptor Antibody Blocking Peptide - LS-E10700 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HTR1A / 5-HT1A Receptor Antibody Blocking Peptide - LS-E27721 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HTR1A / 5-HT1A Receptor Antibody Blocking Peptide - LS-E27722 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human 5-HT1A Protein - H00003350-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human 5-HT1A Protein - H00003350-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

5-HT1A receptor blocking peptide - GTX88400-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Rat, Horse

5-HT1A receptor blocking peptide - GTX89513-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Goat anti Htr1a antibody Immunizing peptide - orb66243 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

HTR1A Blocking Peptide - 33R-3494 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

5-HT1A Blocking Peptide - abx062756 from Abbexa Category Peptide Species Human, Rat, Rabbit

5HT1A receptor Peptide - AC21-2532-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

5HT1A receptor Peptide - AC21-2533-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Serotonin receptor 1A (HTR1A) - H00003350-G01 from Acris Antibodies Category Protein Prices $440.00 Sizes 2 µg Species Human

Serotonin receptor 1A (HTR1A) - H00003350-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Serotonin receptor 1A (HTR1A) - H00003350-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Serotonin receptor 1A (HTR1A) - H00003350-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Serotonin receptor 1A (HTR1A) - H00003350-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Serotonin receptor 1A (HTR1A) Control Peptide - AP09878CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

HTR1A Peptide - 42-342P from ProSci Category Peptide

Recombinant Human HTR1A - HTR1A-148H from Creative Biomart Category Protein Source Mammalian Cells Species Human

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