| Gene Symbol | HTR1A |
|---|---|
| Entrez Gene | 3350 |
| Alt Symbol | 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD |
| Species | Human |
| Gene Type | protein-coding |
| Description | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled |
| Other Description | 5-HT1a receptor|5-hydroxytryptamine receptor 1A|guanine nucleotide-binding regulatory protein-coupled receptor |
| Swissprots | Q6LAE7 P08908 |
| Accessions | AAA36440 AAA66493 BAA94488 CAA31908 CAA40962 CAA77560 CAH03197 EAW51377 P08908 AF498978 AAM21125 AK291429 BAF84118 AK314187 BC069159 AAH69159 BC136263 AAI36264 DA160783 DA223047 DA527925 S64045 AAD13945 NM_000524 NP_000515 |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:22957 |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8393041}; Multi-pass membrane protein {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8393041}. |
| Tissue Specificity | Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells. {ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:8393041}. |
| Top Pathways | cAMP signaling pathway, Neuroactive ligand-receptor interaction |
SR-1A CRISPR/Cas9 KO Plasmid (h) - sc-401329 from Santa Cruz Biotechnology
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SR-1A HDR Plasmid (h) - sc-401329-HDR from Santa Cruz Biotechnology
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SR-1A Double Nickase Plasmid (h) - sc-401329-NIC from Santa Cruz Biotechnology
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SR-1A Double Nickase Plasmid (h2) - sc-401329-NIC-2 from Santa Cruz Biotechnology
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SR-1A CRISPR Activation Plasmid (h) - sc-401329-ACT from Santa Cruz Biotechnology
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SR-1A CRISPR Activation Plasmid (h2) - sc-401329-ACT-2 from Santa Cruz Biotechnology
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SR-1A Lentiviral Activation Particles (h) - sc-401329-LAC from Santa Cruz Biotechnology
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SR-1A Lentiviral Activation Particles (h2) - sc-401329-LAC-2 from Santa Cruz Biotechnology
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SR-1A siRNA (h) - sc-36553 from Santa Cruz Biotechnology
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SR-1A shRNA Plasmid (h) - sc-36553-SH from Santa Cruz Biotechnology
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SR-1A shRNA (h) Lentiviral Particles - sc-36553-V from Santa Cruz Biotechnology
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5-HT1A RNAi - H00003350-R02 from Novus Biologicals
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MISSION® esiRNA - EHU118601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1732 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1732 from Sigma-Aldrich
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HTR1A siRNA (Human) - CRH2281 from Cohesion Biosciences
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HTR1A - MBS8205612 from MyBioSource
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shRNA set against Human HTR1A (NM_000524.3) - SHH315861 from Creative biogene
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Human HTR1A siRNA - orb262783 from Biorbyt
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HTR1A shRNA Plasmid (Human) - CHH2281 from Cohesion Biosciences
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HTR1A miRNA 3'UTR clone - MiUTR4H-TG04356 from Creative biogene
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