PHF1

Gene Symbol	PHF1
Entrez Gene	5252
Alt Symbol	MTF2L2, PCL1, PHF2, TDRD19C, hPHF1
Species	Human
Gene Type	protein-coding
Description	PHD finger protein 1
Other Description	hPCl1|polycomb-like protein 1|tudor domain containing 19C
Swissprots	O60929 Q5SU08 B1AZX2 O43189 B1AZX3 Q5SU07 Q96KM7
Accessions	CAA16158 CAA16159 CAC38366 CAC38367 EAX03729 EAX03730 O43189 AF029678 AAC52062 AF052205 AAC13273 AK225913 AK295412 BAG58363 AK299162 BAG61210 AK316499 BAH14870 BC008834 AAH08834 CB242267 DA065298 DA872118 DQ896419 ABM87418 EU176431 ABW03882 XM_011514662 XP_011512964 XM_011514663 XP_011512965 XM_011514664 XP_011512966 XM_011514665 XP_011512967 XM_011514666 XP_011512968 XM_011514667 XP_011512969 XM_011514668 XP_011512970 XM_011514669 XP_011512971 XM_011514670 XP_011512972 XM_011514671 XP_011512973 XM_011548442 XP_011546744 XM_011548443 XP_011546745 XM_011548444 XP_011546746 XM_011548445 XP_011546747 XM_011548446 XP_011546748 XM_011548447 XP_011546749 XM_011548448 XP_011546750 XM_011548449 XP_011546751 XM_011548450 XP_011546752 XM_011548451 XP_011546753 XR_926249 XR_926250 XR_953080 XR_953081 NM_002636 NP_002627 NM_024165 NP_077084 NR_027692
Function	Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. {ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|Pu
Subcellular Location	Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes specifically to the promoters of numerous target genes. Localizes to double-strand breaks (DSBs) sites following DNA damage. Co- localizes with NEK6 in the centrosome.
Tissue Specificity	Highest levels in heart, skeletal muscle, and pancreas, lower levels in brain, placenta, lung, liver and kidney.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PHF1 ELISA Kit (Sandwich ELISA) - LS-F12327 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.312-20 ng/ml

PHD finger protein 1, PHF1, Human, ELISA Kit - E13279h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Prenylcysteine oxidase 1 (PCYOX1), Human, ELISA Kit - CSB-EL017652HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

PHD finger protein 1, ELISA Kit - MBS9319368 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Prenylcysteine Oxidase 1 (PCYOX1) - SEH428Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.118ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Mouse PHF1 ELISA Kit (Custom ELISA) - LS-F16894 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

PHF1 - EKH2996 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

PHF1 ELISA Kit (Human) (OKEH02297) - OKEH02297 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.21 ng/mL Range 0.312 - 20 ng/mL

Human PHF1 ELISA Kit - E028823 from Biobool Category ELISA Kit Sensitivity <0.188ng/ml

Human PHF2 ELISA Kit - E028834 from Biobool Category ELISA Kit

Human PHD finger protein 1 ELISA Kit - EK3197 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.21ng/ml Range 0.312-20 ng/mL

Human Prenylcysteine oxidase 1 (PCYOX1) ELISA Kit - AE28326HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.118 ng/mL Range 0.312-20 ng/mL

PHD finger protein 1, ELISA Kit - MBS2884874 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.312-20 ng/mL

PHD finger protein 1, ELISA Kit - MBS9427031 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 0.21ng/mL Range 0.312-20 ng/mL

Human PHF1 ELISA Kit (Sandwich ELISA) - LS-F34962 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.188 Range 0.312-20 ng/ml

Search more