PHF1

Gene Symbol	PHF1
Entrez Gene	5252
Alt Symbol	MTF2L2, PCL1, PHF2, TDRD19C, hPHF1
Species	Human
Gene Type	protein-coding
Description	PHD finger protein 1
Other Description	hPCl1|polycomb-like protein 1|tudor domain containing 19C
Swissprots	O60929 Q5SU08 B1AZX2 O43189 B1AZX3 Q5SU07 Q96KM7
Accessions	CAA16158 CAA16159 CAC38366 CAC38367 EAX03729 EAX03730 O43189 AF029678 AAC52062 AF052205 AAC13273 AK225913 AK295412 BAG58363 AK299162 BAG61210 AK316499 BAH14870 BC008834 AAH08834 CB242267 DA065298 DA872118 DQ896419 ABM87418 EU176431 ABW03882 XM_011514662 XP_011512964 XM_011514663 XP_011512965 XM_011514664 XP_011512966 XM_011514665 XP_011512967 XM_011514666 XP_011512968 XM_011514667 XP_011512969 XM_011514668 XP_011512970 XM_011514669 XP_011512971 XM_011514670 XP_011512972 XM_011514671 XP_011512973 XM_011548442 XP_011546744 XM_011548443 XP_011546745 XM_011548444 XP_011546746 XM_011548445 XP_011546747 XM_011548446 XP_011546748 XM_011548447 XP_011546749 XM_011548448 XP_011546750 XM_011548449 XP_011546751 XM_011548450 XP_011546752 XM_011548451 XP_011546753 XR_926249 XR_926250 XR_953080 XR_953081 NM_002636 NP_002627 NM_024165 NP_077084 NR_027692
Function	Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. {ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|Pu
Subcellular Location	Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes specifically to the promoters of numerous target genes. Localizes to double-strand breaks (DSBs) sites following DNA damage. Co- localizes with NEK6 in the centrosome.
Tissue Specificity	Highest levels in heart, skeletal muscle, and pancreas, lower levels in brain, placenta, lung, liver and kidney.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PHF1 full length protein - ab152606 from Abcam Category Protein Source Wheat germ Species Human

Human PHF1 peptide - ab88938 from Abcam Category Peptide

Human PHF1 protein fragment - ab114620 from Abcam Category Protein Source Wheat germ Species Human

PHF1 Antibody Blocking Peptide - LS-E14333 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PHF1 Antibody Blocking Peptide - LS-E14332 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PHF1 Antibody Blocking Peptide - LS-E11632 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PHF2 Antibody Blocking Peptide - LS-E11633 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PHF1 Protein - H00005252-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human PHF1 Protein - H00005252-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PHF2 Protein - H00005253-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PHF1 - H00005252-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

PHF1 - H00005252-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PHF1 - H00005252-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PHF1 fusion protein - Ag8166 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PHF1 fusion protein - Ag8094 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human PHF1 - PHF1-30328TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human PHF1, His-tagged - PHF1-1679H from Creative Biomart Category Protein Source E.coli Species Human

PHF1 (K381) Peptide - BS2453P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Prenylcysteine Oxidase 1 (PCYOX1) - RPH428Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human PHD finger protein 1(PHF1) - CSB-YP017897HU CSB-EP017897HU CSB-BP017897HU CSB-MP017897HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PHF1 Protein - abx163329 from Abbexa Category Protein Species Human, Mouse

PHD finger protein 1 (PHF1), Recombinant Protein - MBS1240303 from MyBioSource Category Protein Prices $1,365.00, $1,365.00, $1,585.00, $1,585.00, $2,270.00, $2,270.00, $2,730.00, $2,730.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PHF2 Recombinant Protein Antigen - NBP1-83080PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PHF1 Blocking Peptide - abx061049 from Abbexa Category Peptide Species Human, Bovine, Dog, Rabbit

PHF1 Recombinant Protein Antigen - NBP1-82613PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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