PHF1

Gene Symbol	PHF1
Entrez Gene	5252
Alt Symbol	MTF2L2, PCL1, PHF2, TDRD19C, hPHF1
Species	Human
Gene Type	protein-coding
Description	PHD finger protein 1
Other Description	hPCl1|polycomb-like protein 1|tudor domain containing 19C
Swissprots	O60929 Q5SU08 B1AZX2 O43189 B1AZX3 Q5SU07 Q96KM7
Accessions	CAA16158 CAA16159 CAC38366 CAC38367 EAX03729 EAX03730 O43189 AF029678 AAC52062 AF052205 AAC13273 AK225913 AK295412 BAG58363 AK299162 BAG61210 AK316499 BAH14870 BC008834 AAH08834 CB242267 DA065298 DA872118 DQ896419 ABM87418 EU176431 ABW03882 XM_011514662 XP_011512964 XM_011514663 XP_011512965 XM_011514664 XP_011512966 XM_011514665 XP_011512967 XM_011514666 XP_011512968 XM_011514667 XP_011512969 XM_011514668 XP_011512970 XM_011514669 XP_011512971 XM_011514670 XP_011512972 XM_011514671 XP_011512973 XM_011548442 XP_011546744 XM_011548443 XP_011546745 XM_011548444 XP_011546746 XM_011548445 XP_011546747 XM_011548446 XP_011546748 XM_011548447 XP_011546749 XM_011548448 XP_011546750 XM_011548449 XP_011546751 XM_011548450 XP_011546752 XM_011548451 XP_011546753 XR_926249 XR_926250 XR_953080 XR_953081 NM_002636 NP_002627 NM_024165 NP_077084 NR_027692
Function	Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. {ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|Pu
Subcellular Location	Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes specifically to the promoters of numerous target genes. Localizes to double-strand breaks (DSBs) sites following DNA damage. Co- localizes with NEK6 in the centrosome.
Tissue Specificity	Highest levels in heart, skeletal muscle, and pancreas, lower levels in brain, placenta, lung, liver and kidney.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PHF1 CRISPR/Cas9 KO Plasmid (h) - sc-405911 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PHF1 HDR Plasmid (h) - sc-405911-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PHF1 Double Nickase Plasmid (h) - sc-405911-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PHF1 Double Nickase Plasmid (h2) - sc-405911-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PHF1 CRISPR Activation Plasmid (h) - sc-405911-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PHF1 CRISPR Activation Plasmid (h2) - sc-405911-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PHF1 Lentiviral Activation Particles (h) - sc-405911-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PHF1 Lentiviral Activation Particles (h2) - sc-405911-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PHF1 siRNA (h) - sc-95264 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PHF1 shRNA Plasmid (h) - sc-95264-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PHF1 shRNA (h) Lentiviral Particles - sc-95264-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PHF2 RNAi - H00005253-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PHF1 RNAi - H00005252-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PHF1 RNAi - H00005252-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PHF2 RNAi - H00005253-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU023731 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® esiRNA - EHU092931 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16714 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16714 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05619 from Sigma-Aldrich Category miRNA

PHF1 siRNA (Human) - CRH3506 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human PHF1 (NM_002636.4) - SHH374596 from Creative biogene Category siRNA Species Reactivities Human

Human PHF1 siRNA - orb264008 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PHF1 shRNA Plasmid (Human) - CHH3506 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

PHF1 miRNA 3'UTR clone - MiUTR3H-05379 from Creative biogene Species Reactivities Human

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