| Gene Symbol |
OMA1
|
| Entrez Gene |
115209
|
| Alt Symbol |
2010001O09Rik, DAB1, MPRP-1, YKR087C, ZMPOMA1, peptidase
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
OMA1 zinc metallopeptidase
|
| Other Description |
OMA1 homolog, zinc metallopeptidase|OMA1 zinc metallopeptidase homolog|metalloendopeptidase OMA1, mitochondrial|metalloprotease related protein 1|metalloprotease-related protein 1|overlapping activity with M-AAA protease|overlapping with the m-AAA protease 1 homolog|zinc metallopeptidase OMA1
|
| Swissprots |
Q5T3G8 Q96E52 Q5T3G6 D3DQ54 Q8NBB3 Q5T3H0 Q5T3G9 Q5T3G7
|
| Accessions |
CAE48420 EAX06631 EAX06632 EAX06633 EAX06634 Q96E52 AB048348 BAC79381 AK091101 BAC03583 AK308847 BC012915 AAH12915 BU191827 JF432270 ADZ15487 NM_145243 NP_660286
|
| Function |
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. {ECO:0000269|PubMed:20038677}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000305|PubMed:20038677}; Multi-pass membrane protein {ECO:0000305|PubMed:20038677}.
|
| Tissue Specificity |
Widely expressed, with strong expression in the heart, skeletal muscle, kidney and liver. {ECO:0000269|PubMed:12886954}.
|