NAT8

Gene Symbol	NAT8
Entrez Gene	9027
Alt Symbol	ATase2, CCNAT, CML1, GLA, Hcml1, TSC501, TSC510
Species	Human
Gene Type	protein-coding
Description	N-acetyltransferase 8 (GCN5-related, putative)
Other Description	N-acetyltransferase 8|N-acetyltransferase 8 (camello like)|acetyltransferase 2|camello-like protein 1|cysteinyl-conjugate N-acetyltransferase|kidney- and liver-specific gene product|probable N-acetyltransferase 8
Swissprots	Q9UHE5 O75839 Q6LEU4 Q9UQ17 Q96QI8
Accessions	EAW99727 Q9UHE5 AB013094 BAA33679 AB019551 BAA34386 AF187813 AAF22303 BC012626 AAH12626 BG426653 CR407610 CAG28538 JF432583 ADZ15800 NM_003960 NP_003951
Function	Acetylates the free alpha-amino group of cysteine S- conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S- conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6- acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241). {ECO:0000269|PubMed:19011241, ECO:0000269|PubMed:20392701, ECO:0000269|PubMed:24556617}.
Subcellular Location	Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Tissue Specificity	Preferentially expressed in liver and kidney. Also detected in brain (at protein level). {ECO:0000269|PubMed:22267734, ECO:0000269|PubMed:9852678}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NAT-8 (L-12) - sc-139400 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-NAT8 antibody - ab197793 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NAT8 antibody [5A8] - ab117977 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5A8

Anti-TSC501 / NAT8 Antibody (clone 6H3) - LS-C114627 from LifeSpan Bioscience Prices $350.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 6H3

Anti-TSC501 / NAT8 Antibody (clone 5A8) - LS-C114641 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5A8

Anti-TSC501 / NAT8 Antibody (aa110-138, AP) - LS-C264022 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TSC501 / NAT8 Antibody (aa110-138, Biotin) - LS-C264024 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TSC501 / NAT8 Antibody (aa110-138, APC) - LS-C264023 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TSC501 / NAT8 Antibody (aa110-138, FITC) - LS-C264025 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TSC501 / NAT8 Antibody (aa110-138, Azide-free, HRP) - LS-C264026 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TSC501 / NAT8 Antibody (aa120-150) - LS-C323241 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TSC501 / NAT8 Antibody (aa110-138, PE) - LS-C264027 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TSC501 / NAT8 Antibody (aa110-138) - LS-C164757 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

NAT8 Antibody (5A8) - NBP1-47863 from Novus Biologicals Prices $379.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5A8

Rabbit Anti-NAT8/NAT8B Polyclonal Antibody - bs-11591R from Bioss Prices $245.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-NAT8/NAT8B Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11591R-A350 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-NAT8/NAT8B Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11591R-A488 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-NAT8/NAT8B Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11591R-A555 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-NAT8/NAT8B Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11591R-A647 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-NAT8/NAT8B Polyclonal Antibody, Cy3 Conjugated - bs-11591R-Cy3 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-NAT8/NAT8B Polyclonal Antibody, Cy5 Conjugated - bs-11591R-Cy5 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-NAT8/NAT8B Polyclonal Antibody, Cy5.5 Conjugated - bs-11591R-Cy5.5 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-NAT8/NAT8B Polyclonal Antibody, Cy7 Conjugated - bs-11591R-Cy7 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-NAT8/NAT8B Polyclonal Antibody, FITC Conjugated - bs-11591R-FITC from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-NAT8/NAT8B Polyclonal Antibody, Biotin Conjugated - bs-11591R-Biotin from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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