| Gene Symbol | NAT8 |
|---|---|
| Entrez Gene | 9027 |
| Alt Symbol | ATase2, CCNAT, CML1, GLA, Hcml1, TSC501, TSC510 |
| Species | Human |
| Gene Type | protein-coding |
| Description | N-acetyltransferase 8 (GCN5-related, putative) |
| Other Description | N-acetyltransferase 8|N-acetyltransferase 8 (camello like)|acetyltransferase 2|camello-like protein 1|cysteinyl-conjugate N-acetyltransferase|kidney- and liver-specific gene product|probable N-acetyltransferase 8 |
| Swissprots | Q9UHE5 O75839 Q6LEU4 Q9UQ17 Q96QI8 |
| Accessions | EAW99727 Q9UHE5 AB013094 BAA33679 AB019551 BAA34386 AF187813 AAF22303 BC012626 AAH12626 BG426653 CR407610 CAG28538 JF432583 ADZ15800 NM_003960 NP_003951 |
| Function | Acetylates the free alpha-amino group of cysteine S- conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S- conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6- acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241). {ECO:0000269|PubMed:19011241, ECO:0000269|PubMed:20392701, ECO:0000269|PubMed:24556617}. |
| Subcellular Location | Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. |
| Tissue Specificity | Preferentially expressed in liver and kidney. Also detected in brain (at protein level). {ECO:0000269|PubMed:22267734, ECO:0000269|PubMed:9852678}. |
NAT-8 CRISPR/Cas9 KO Plasmid (h) - sc-411236 from Santa Cruz Biotechnology
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NAT-8 HDR Plasmid (h) - sc-411236-HDR from Santa Cruz Biotechnology
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NAT-8 Double Nickase Plasmid (h) - sc-411236-NIC from Santa Cruz Biotechnology
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NAT-8 Double Nickase Plasmid (h2) - sc-411236-NIC-2 from Santa Cruz Biotechnology
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NAT-8 CRISPR Activation Plasmid (h) - sc-411236-ACT from Santa Cruz Biotechnology
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NAT-8 CRISPR Activation Plasmid (h2) - sc-411236-ACT-2 from Santa Cruz Biotechnology
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NAT-8 Lentiviral Activation Particles (h) - sc-411236-LAC from Santa Cruz Biotechnology
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NAT-8 Lentiviral Activation Particles (h2) - sc-411236-LAC-2 from Santa Cruz Biotechnology
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NAT-8 siRNA (h) - sc-94277 from Santa Cruz Biotechnology
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NAT-8 shRNA Plasmid (h) - sc-94277-SH from Santa Cruz Biotechnology
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NAT-8 shRNA (h) Lentiviral Particles - sc-94277-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU109981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14970 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14970 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00961 from Sigma-Aldrich
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NAT8 siRNA (Human) - CRH5954 from Cohesion Biosciences
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shRNA set against Human NAT8 (NM_003960.3) - SHH349524 from Creative biogene
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shRNA set against Human NAT8(NM_003960.3) - SHG184827 from Creative biogene
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Human NAT8 siRNA - orb266456 from Biorbyt
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NAT8 shRNA Plasmid (Human) - CHH5954 from Cohesion Biosciences
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NAT8 miRNA 3'UTR clone - MiUTR1H-06650 from Creative biogene
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