| Gene Symbol |
NAT8
|
| Entrez Gene |
9027
|
| Alt Symbol |
ATase2, CCNAT, CML1, GLA, Hcml1, TSC501, TSC510
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
N-acetyltransferase 8 (GCN5-related, putative)
|
| Other Description |
N-acetyltransferase 8|N-acetyltransferase 8 (camello like)|acetyltransferase 2|camello-like protein 1|cysteinyl-conjugate N-acetyltransferase|kidney- and liver-specific gene product|probable N-acetyltransferase 8
|
| Swissprots |
Q9UHE5 O75839 Q6LEU4 Q9UQ17 Q96QI8
|
| Accessions |
EAW99727 Q9UHE5 AB013094 BAA33679 AB019551 BAA34386 AF187813 AAF22303 BC012626 AAH12626 BG426653 CR407610 CAG28538 JF432583 ADZ15800 NM_003960 NP_003951
|
| Function |
Acetylates the free alpha-amino group of cysteine S- conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S- conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6- acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241). {ECO:0000269|PubMed:19011241, ECO:0000269|PubMed:20392701, ECO:0000269|PubMed:24556617}.
|
| Subcellular Location |
Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.
|
| Tissue Specificity |
Preferentially expressed in liver and kidney. Also detected in brain (at protein level). {ECO:0000269|PubMed:22267734, ECO:0000269|PubMed:9852678}.
|