NAT8

Gene Symbol	NAT8
Entrez Gene	9027
Alt Symbol	ATase2, CCNAT, CML1, GLA, Hcml1, TSC501, TSC510
Species	Human
Gene Type	protein-coding
Description	N-acetyltransferase 8 (GCN5-related, putative)
Other Description	N-acetyltransferase 8|N-acetyltransferase 8 (camello like)|acetyltransferase 2|camello-like protein 1|cysteinyl-conjugate N-acetyltransferase|kidney- and liver-specific gene product|probable N-acetyltransferase 8
Swissprots	Q9UHE5 O75839 Q6LEU4 Q9UQ17 Q96QI8
Accessions	EAW99727 Q9UHE5 AB013094 BAA33679 AB019551 BAA34386 AF187813 AAF22303 BC012626 AAH12626 BG426653 CR407610 CAG28538 JF432583 ADZ15800 NM_003960 NP_003951
Function	Acetylates the free alpha-amino group of cysteine S- conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S- conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6- acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241). {ECO:0000269|PubMed:19011241, ECO:0000269|PubMed:20392701, ECO:0000269|PubMed:24556617}.
Subcellular Location	Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Tissue Specificity	Preferentially expressed in liver and kidney. Also detected in brain (at protein level). {ECO:0000269|PubMed:22267734, ECO:0000269|PubMed:9852678}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NAT8 full length protein - ab160299 from Abcam Category Protein Source Wheat germ Species Human

TSC501 / NAT8 Antibody Blocking Peptide - LS-E7664 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human NAT8 Protein - H00009027-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NAT8-Antibody-Center-Blocking-Peptide - BP4957c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NAT8 - H00009027-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NAT8 - H00009027-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NAT8 fusion protein - Ag1353 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human NAT8, GST-tagged - NAT8-1195H from Creative Biomart Category Protein Source E.coli Species Human

NAT8 Protein - abx164454 from Abbexa Category Protein Species Human, Mouse, Rat

NAT8 - TP303157 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

NAT8 Peptide, Human - M34GP10141H from Creative Peptides Category Peptide Source Synthetic. Species Human

NAT8 Recombinant Protein Antigen - NBP2-57444PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Probable N-acetyltransferase 8 (NAT8), Recombinant Protein - MBS7022664 from MyBioSource Category Protein Prices $1,045.00, $2,030.00, $3,240.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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