IL11RA

Gene Symbol	IL11RA
Entrez Gene	3590
Alt Symbol	CRSDA
Species	Human
Gene Type	protein-coding
Description	interleukin 11 receptor, alpha
Other Description	IL-11 receptor subunit alpha|IL-11R subunit alpha|interleukin-11 receptor alpha chain|interleukin-11 receptor subunit alpha
Swissprots	Q5VZ80 Q14626 Q7KYJ7 Q16542
Accessions	AAB36491 AAS00093 EAW58422 EAW58423 EAW58424 EAW58425 Q14626 AI377039 AK075530 AK094689 BAG52913 AK292073 BAF84762 BC003110 AAH03110 BT009864 AAP88866 DA917660 DC424068 DQ892342 ABM83268 DQ895548 ABM86474 U32324 AAB36492 Z38102 CAA86224 Z46595 CAA86570 NM_001142784 NP_001136256 NR_052010 NM_004512 NM_147162
Function	Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. {ECO:0000269|PubMed:21741611}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2. Also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma. {ECO:0000269|PubMed:11141475}.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IL11RA-Over-expression-Lysate - LY13389a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

IL11RA Overexpression Lysate (Native) - NBL1-11899 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

IL-11Rα (h): 293 Lysate - sc-176002 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

IL11RA Over-expression Lysate Product - GWB-C8FCB1 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human IL11RA / IL11Rα HEK293 Cell Lysate (WB positive control) - 10252-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

IL11RA Overexpression Lysate (Native) - NBP2-09671 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Human IL11RA Human Cells Transfected Lysate (positive control) (denatured) - orb173437 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human IL11RA Knockdown Stable Cell Line - CSC-DC007532 from Creative biogene Category Cell Line Species Human

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