IL11RA

Gene Symbol IL11RA
Entrez Gene 3590
Alt Symbol CRSDA
Species Human
Gene Type protein-coding
Description interleukin 11 receptor, alpha
Other Description IL-11 receptor subunit alpha|IL-11R subunit alpha|interleukin-11 receptor alpha chain|interleukin-11 receptor subunit alpha
Swissprots Q5VZ80 Q14626 Q7KYJ7 Q16542
Accessions AAB36491 AAS00093 EAW58422 EAW58423 EAW58424 EAW58425 Q14626 AI377039 AK075530 AK094689 BAG52913 AK292073 BAF84762 BC003110 AAH03110 BT009864 AAP88866 DA917660 DC424068 DQ892342 ABM83268 DQ895548 ABM86474 U32324 AAB36492 Z38102 CAA86224 Z46595 CAA86570 NM_001142784 NP_001136256 NR_052010 NM_004512 NM_147162
Function Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. {ECO:0000269|PubMed:21741611}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2. Also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma. {ECO:0000269|PubMed:11141475}.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage

IL-11Rα (4D12) - sc-130920 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-11Rα (4D12): sc-130920. Western blot analysis of IL-11Rα expression in non-transfected: sc-110760 (A) and human IL-11Rα transfected: sc-176002 (B) 293 whole cell lysates.

IL-11Rα (N-20) - sc-993 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-11Ra (N-20) PE: sc-993 PE. Intracellular FCM analysis of fixed and permeabilized 3T3-L1 cells. Black line histogram represents the isotype control, normal rabbit IgG: sc-3871.

IL-11Rα (H-300) - sc-25476 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-11Rα (H-300): sc-25476. Western blot analysis of IL-11Rα expression in non-transfected: sc-117752 (A) and mouse IL-11Rα transfected: sc-125492 (B) 293T whole cell lysates.

IL-11Rα (K-20) - sc-1947 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IL-11Rα (A-13) - sc-31419 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-IL11RA antibody - ab109697 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL11RA antibody (ab109697) at 1/1000 dilutionLane 1 : Human fetal liver lysateLane 2 : Human fetal heart lysateLane 3 : Human fetal colon lysate

Anti-IL11RA antibody - ab84328 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-IL11RA antibody (ab84328) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal muscle lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-IL11RA antibody - ab84316 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-IL11RA antibody (ab84316) at 1 µg/ml + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-IL11RA antibody - ab55262 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-IL11RA antibody [EPR5446] - ab125015 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5446
Overlay histogram showing K562 cells stained with ab125015 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab125015, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in K562 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-IL11RA Antibody (aa59-217) - LS-C294826 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant IL11RA.

Anti-IL11RA Antibody (aa59-220) - LS-C294823 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant IL11RA.

Anti-IL11RA Antibody - LS-C178440 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-IL11RA Antibody (aa1-423, clone 2D4-F4) - LS-C130250 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D4-F4

Anti-IL11RA Antibody (Asp361) - LS-C193265 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL11RA Antibody (aa59-217, Biotin) - LS-C297165 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL11RA Antibody (aa59-220, Biotin) - LS-C299772 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL11RA Antibody (aa194-329, Biotin) - LS-C299875 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL11RA Antibody (aa194-329, FITC) - LS-C302034 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL11RA Antibody (aa59-220, FITC) - LS-C303192 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL11RA Antibody (aa252-301) - LS-C102230 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IL11RA antibody LS-C102230 Western blot of Fetal Muscle lysate.

Anti-IL11RA Antibody (aa59-217, FITC) - LS-C303961 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL11RA Antibody (aa1-423, Azide-free) - LS-C327651 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-IL11RA Antibody (aa108-157) - LS-C102231 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IL11RA antibody LS-C102231 Western blot of Jurkat lysate.

Anti-IL11RA Antibody (Internal, clone EPR5446) - LS-C138974 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5446
IHC of paraffin-embedded human kidney tissue using anti-IL-11R alpha antibody.
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